Department of Faculty Therapy, Northern State Medical University, Arkhangelsk 163069, Russia.
International Research Competence Centre, Northern State Medical University, Arkhangelsk 163069, Russia.
Biomolecules. 2023 May 14;13(5):835. doi: 10.3390/biom13050835.
Mortality from cardiovascular diseases (CVDs) is higher in Russia compared to other European countries. High-sensitivity C-reactive protein (hs-CRP) is a biomarker of inflammation, and its elevated levels indicate increased CVD risks. We aim to describe the prevalence of low-grade systemic inflammation (LGSI) and the associated factors in a Russian population. The Know Your Heart cross-sectional study was conducted in Arkhangelsk, Russia in 2015-2017 with a population sample aged 35-69 years ( = 2380). LGSI was defined as hs-CRP ≥ 2 and <10 mg/L, and its associations with socio-demographic, lifestyle, and cardiometabolic characteristics were analyzed. The prevalence of LGSI (age-standardized to European Standard Population 2013) was 34.1% (33.5% in men and 36.1% in women). In the total sample, the increased odds ratios (ORs) of LGSI were associated with abdominal obesity (2.1), smoking (1.9), dyslipidemia (1.5), pulmonary diseases (1.4), and hypertension (1.3); the decreased ORs were in women (0.6) and in married participants (0.6). In men, the ORs were higher with abdominal obesity (2.1), smoking (2.0), CVDs (1.5), and hazardous drinking (1.5); in women-with abdominal obesity (4.4) and pulmonary diseases (1.5). In conclusion, one-third of the adult population in Arkhangelsk had LGSI. Abdominal obesity was the strongest LGSI correlate in both sexes, while the profiles of other associated factors were different between men and women.
心血管疾病（CVDs）导致的死亡率在俄罗斯高于其他欧洲国家。高敏 C 反应蛋白（hs-CRP）是炎症的生物标志物，其水平升高表明 CVD 风险增加。我们旨在描述俄罗斯人群中低度全身性炎症（LGSI）的流行情况及其相关因素。2015-2017 年在俄罗斯阿尔汉格尔斯克进行了 Know Your Heart 横断面研究，研究对象为 35-69 岁的人群样本（=2380）。LGSI 的定义为 hs-CRP≥2 且<10mg/L，并分析其与社会人口统计学、生活方式和心血管代谢特征的相关性。LGSI 的流行率（按 2013 年欧洲标准人口年龄标准化）为 34.1%（男性为 33.5%，女性为 36.1%）。在总样本中，LGSI 的比值比（OR）与腹部肥胖（2.1）、吸烟（1.9）、血脂异常（1.5）、肺部疾病（1.4）和高血压（1.3）相关；而与女性（0.6）和已婚参与者（0.6）相关的 OR 降低。在男性中，OR 与腹部肥胖（2.1）、吸烟（2.0）、CVDs（1.5）和危险饮酒（1.5）相关更高；在女性中，与腹部肥胖（4.4）和肺部疾病（1.5）相关。总之，阿尔汉格尔斯克有三分之一的成年人口存在 LGSI。腹部肥胖是两性中与 LGSI 相关性最强的因素，而其他相关因素的特征在男性和女性之间有所不同。
