Kida Dorota, Konopka Tomasz, Jurczyszyn Kamil, Karolewicz Bożena
Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
Department of Periodontology, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland.
Biomedicines. 2023 Apr 25;11(5):1274. doi: 10.3390/biomedicines11051274.
The development of polymer matrices as dental drug carriers takes into account the following technological aspects of the developed formulations: the composition and the technology used to manufacture them, which affect the properties of the carriers, as well as the testing methods for assessing their behavior at application sites. The first part of this paper characterizes the methods for fabricating dental drug carriers, i.e., the solvent-casting method (SCM), lyophilization method (LM), electrospinning (ES) and 3D printing (3DP), describing the selection of technological parameters and pointing out both the advantages of using the mentioned methods and their limitations. The second part of this paper describes testing methods to study the formulation properties, including their physical and chemical, pharmaceutical, biological and in vivo evaluation. Comprehensive in vitro evaluation of carrier properties permits optimization of formulation parameters to achieve prolonged retention time in the dynamic oral environment and is essential for explaining carrier behavior during clinical evaluation, consequently enabling the selection of the optimal formulation for oral application.
用于制造它们的组成和技术，这会影响载体的性能，以及评估其在应用部位行为的测试方法。本文的第一部分描述了制造牙科药物载体的方法，即溶剂浇铸法（SCM）、冻干法（LM）、静电纺丝（ES）和3D打印（3DP），阐述了技术参数的选择，并指出了使用上述方法的优点及其局限性。本文的第二部分描述了研究制剂性质的测试方法，包括其物理化学、药学、生物学和体内评价。对载体性质进行全面的体外评价有助于优化制剂参数，以在动态口腔环境中实现延长的保留时间，并且对于解释临床评价期间的载体行为至关重要，从而能够选择最佳的口服制剂。
