Damian Ioana, Muntean George-Adrian, Galea-Holhoș Larisa-Bianca, Nicoară Simona-Delia
Department of Ophthalmology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
Department of Anatomy, Faculty of Medicine and Pharmacy, University of Oradea, 1 Decembrie Street, 410068 Oradea, Romania.
Biomedicines. 2023 May 6;11(5):1382. doi: 10.3390/biomedicines11051382.
Acquired vitelliform lesions (AVLs) are associated with a large spectrum of retinal diseases, among which is age-related macular degeneration (AMD). The purpose of this study was to characterize AVLs' evolution in AMD patients using optical coherence tomography (OCT) technology and ImageJ software. We measured AVLs' size and density and followed their impacts over surrounding retinal layers. Average retinal pigment epithelium (RPE) thickness in the central 1 mm quadrant (45.89 ± 27.84 µm vs. 15.57 ± 1.40 µm) was significantly increased, as opposed to the outer nuclear layer (ONL) thickness, which was decreased (77.94 ± 18.30 µm vs. 88.64 ± 7.65 µm) in the vitelliform group compared to the control group. We found a continuous external limiting membrane (ELM) in 55.5% of the eyes compared to a continuous ellipsoid zone (EZ) in 22.2% of the eyes in the vitelliform group. The difference between the mean AVLs' volume at baseline compared to the last visit for the nine eyes with ophthalmologic follow-up was not statistically significant ( = 0.725). The median follow-up duration was 11 months (range 5-56 months). Seven eyes (43.75%) were treated with intravitreal anti-vascular endothelium growth factor (anti-VEGF) agent injections, in which we noted a 6.43 ± 9 letter decrease in the best-corrected visual acuity (BCVA). The increased RPE thickness could suggest hyperplasia contrary to the decreased ONL, which could mirror the impact of the vitelliform lesion on photoreceptors (PR). Eyes that received anti-VEGF injections did not show signs of improvement regarding BCVA.
获得性卵黄样病变（AVL）与多种视网膜疾病相关，其中包括年龄相关性黄斑变性（AMD）。本研究的目的是使用光学相干断层扫描（OCT）技术和ImageJ软件来描述AMD患者中AVL的演变情况。我们测量了AVL的大小和密度，并跟踪其对周围视网膜层的影响。与对照组相比，黄斑中心1mm象限的平均视网膜色素上皮（RPE）厚度显著增加（45.89±27.84μm vs. 15.57±1.40μm），而卵黄样病变组的外核层（ONL）厚度则降低（77.94±18.30μm vs. 88.64±7.65μm）。卵黄样病变组中，55.5%的眼睛存在连续的外界膜（ELM），而22.2%的眼睛存在连续的椭圆体带（EZ）。在有眼科随访的9只眼中，基线时与最后一次随访时AVL的平均体积差异无统计学意义（ = 0.725）。中位随访时间为11个月（范围5 - 56个月）。7只眼（43.75%）接受了玻璃体内抗血管内皮生长因子（抗VEGF）药物注射，其中我们注意到最佳矫正视力（BCVA）下降了6.43±9字母。RPE厚度增加可能提示增生，与ONL厚度降低相反，这可能反映了卵黄样病变对光感受器（PR）的影响。接受抗VEGF注射的眼睛在BCVA方面未显示改善迹象。
