Frisardi Vincenza, Pollorsi Chiara, Sambati Luisa, Macchiarulo Maria, Fabbo Andrea, Neviani Francesca, Menchetti Marco, Chattat Rabih
Geriatric Unit Neuromotor Department, AUSL-IRCCS of Reggio Emilia, 80 Risorgimento Avenue Reggio Emilia, 46123 Reggio Emilia, Italy.
U.O.C. Clinica Neurologica Rete Metropolitana (NeuroMet), IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Biomedicines. 2023 May 11;11(5):1418. doi: 10.3390/biomedicines11051418.
Older adults with mood disorders constitute a heterogeneous group in a complex spectrum interlinked with physical comorbidities. Worldwide, Bipolar disorders in older people (OABD) remain underestimated and underdiagnosed. OABD is challenging in the clinical setting and is associated with adverse outcomes (increased risk of anti-social behaviour triggered by inappropriate drugs and increased incidence of health deficits, including cancer). This article aims to describe the state of the art of OABD in the Italian framework and provide a new field of research.
We performed an overview of the literature, selecting our target population (over 65 years) and synthesising the main challenging issues. By exploiting the Italian database from the Minister of Health in 2021, we analysed epidemiological data in the age range 65-74 years and 75-84 years old.
Females showed the highest prevalence and incidence in both groups, with a regional difference across the country but more evident in the Autonomous Provinces of Bolzano and Trento for the 65-74 years range. Several projects recently focused on this topic, and the urgency to define better the epidemiological framework is mandatory.
This study represented the first attempt to report the comprehensive Italian framework on OABD aimed at fostering research activities and knowledge.
患有情绪障碍的老年人构成了一个异质性群体，处于与身体合并症相互关联的复杂谱系中。在全球范围内，老年双相情感障碍（OABD）仍然被低估和漏诊。OABD在临床环境中具有挑战性，并且与不良后果相关（不适当药物引发的反社会行为风险增加以及包括癌症在内的健康缺陷发生率增加）。本文旨在描述意大利框架下OABD的现状，并提供一个新的研究领域。
我们对文献进行了综述，选择目标人群（65岁以上）并综合主要的挑战性问题。通过利用2021年意大利卫生部的数据库，我们分析了65至74岁和75至84岁年龄范围内的流行病学数据。
两组中女性的患病率和发病率最高，在全国范围内存在地区差异，但在65至74岁年龄段的博尔扎诺和特伦托自治省更为明显。最近有几个项目关注这个主题，必须迫切地更好地界定流行病学框架。
本研究首次尝试报告意大利关于OABD的综合框架，旨在促进研究活动和知识。
