• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

含人脂肪干细胞的肝素基水凝胶微贴片：一种缓解神经性疼痛的有前景的治疗方法。

Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief.

作者信息

Lee HyeYeong, Tae GiYoong, Hwang SaeYeon, Wee SungWon, Ha Yoon, Lee Hye-Lan, Shin DongAh

机构信息

Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea.

School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.

出版信息

Biomedicines. 2023 May 12;11(5):1436. doi: 10.3390/biomedicines11051436.

DOI:10.3390/biomedicines11051436
PMID:37239107
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10216470/
Abstract

This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-based hydrogel micropatches in the neuropathic pain animal model. The use of this combination also produced enhanced cell viability and nerve regeneration. We conducted various neurological behavioral tests, dynamic plantar tests, histological examinations, and neuroelectrophysiological examinations to confirm the therapeutic effect. Our findings suggest that this approach could maximize therapeutic efficacy and improve the quality of life for patients suffering from neuropathic pain.

摘要

本研究探讨了含人脂肪来源干细胞（hASCs）的肝素基水凝胶微贴片在治疗神经损伤所致神经性疼痛方面的治疗效果。我们的结果表明，在神经性疼痛动物模型中，hASCs与肝素基水凝胶微贴片联合使用时表现出神经再生和止痛作用。这种联合使用还提高了细胞活力并促进了神经再生。我们进行了各种神经行为测试、动态足底测试、组织学检查和神经电生理检查以证实治疗效果。我们的研究结果表明，这种方法可以最大限度地提高治疗效果，并改善神经性疼痛患者的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/a913315d0f7e/biomedicines-11-01436-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/23aeda59bf65/biomedicines-11-01436-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/bf41b6f6fab6/biomedicines-11-01436-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/0001cbb44d5c/biomedicines-11-01436-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/08ef8211adb0/biomedicines-11-01436-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/a913315d0f7e/biomedicines-11-01436-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/23aeda59bf65/biomedicines-11-01436-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/bf41b6f6fab6/biomedicines-11-01436-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/0001cbb44d5c/biomedicines-11-01436-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/08ef8211adb0/biomedicines-11-01436-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3efa/10216470/a913315d0f7e/biomedicines-11-01436-g005.jpg

相似文献

1
Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief.含人脂肪干细胞的肝素基水凝胶微贴片：一种缓解神经性疼痛的有前景的治疗方法。
Biomedicines. 2023 May 12;11(5):1436. doi: 10.3390/biomedicines11051436.
2
Injectable and detachable heparin-based hydrogel micropatches for hepatic differentiation of hADSCs and their liver targeted delivery.可注射和可分离的基于肝素的水凝胶微贴剂，用于 hADSCs 的肝向分化及其肝靶向递送。
Biomaterials. 2018 May;165:94-104. doi: 10.1016/j.biomaterials.2018.03.001. Epub 2018 Mar 3.
3
Human decellularized adipose matrix derived hydrogel assists mesenchymal stem cells delivery and accelerates chronic wound healing.人去细胞脂肪基质衍生水凝胶辅助间充质干细胞递送并加速慢性伤口愈合。
J Biomed Mater Res A. 2021 Aug;109(8):1418-1428. doi: 10.1002/jbm.a.37133. Epub 2020 Dec 9.
4
Systemic administration of human adipose-derived stem cells reverts nociceptive hypersensitivity in an experimental model of neuropathy.系统给予人脂肪来源干细胞可逆转神经病变实验模型中的痛觉过敏。
Stem Cells Dev. 2013 Apr 15;22(8):1252-63. doi: 10.1089/scd.2012.0398. Epub 2013 Jan 9.
5
Human Adipose Stem Cells Improve Mechanical Allodynia and Enhance Functional Recovery in a Rat Model of Neuropathic Pain.人脂肪干细胞改善神经性疼痛大鼠模型的机械性异常性疼痛并促进功能恢复。
Tissue Eng Part A. 2015 Jul;21(13-14):2044-52. doi: 10.1089/ten.TEA.2014.0713. Epub 2015 May 20.
6
Hydrogel-based microreactors as a functional component of microfluidic systems.基于水凝胶的微反应器作为微流控系统的功能组件。
Anal Chem. 2002 Sep 15;74(18):4647-52. doi: 10.1021/ac020340y.
7
Enzyme-Cross-linked Gelatin Hydrogel Enriched with an Articular Cartilage Extracellular Matrix and Human Adipose-Derived Stem Cells for Hyaline Cartilage Regeneration of Rabbits.富含关节软骨细胞外基质和人脂肪来源干细胞的酶交联明胶水凝胶用于兔透明软骨再生
ACS Biomater Sci Eng. 2020 Sep 14;6(9):5110-5119. doi: 10.1021/acsbiomaterials.9b01756. Epub 2020 Jul 31.
8
A cocktail of growth factors released from a heparin hyaluronic-acid hydrogel promotes the myogenic potential of human urine-derived stem cells in vivo.从肝素透明质酸水凝胶中释放的生长因子鸡尾酒在体内促进了人尿源性干细胞的成肌潜能。
Acta Biomater. 2020 Apr 15;107:50-64. doi: 10.1016/j.actbio.2020.02.005. Epub 2020 Feb 8.
9
Hybrid Synthetic-Biological Hydrogel System for Adipose Tissue Regeneration.用于脂肪组织再生的杂交合成-生物水凝胶系统。
Macromol Biosci. 2018 Nov;18(11):e1800122. doi: 10.1002/mabi.201800122. Epub 2018 Sep 24.
10
Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain.脂肪组织来源的干细胞可减轻大鼠坐骨神经结扎神经性疼痛模型中的冷痛觉过敏
Stem Cells Int. 2020 Oct 12;2020:8845262. doi: 10.1155/2020/8845262. eCollection 2020.

引用本文的文献

1
Optimization strategies for mesenchymal stem cell-based analgesia therapy: a promising therapy for pain management.基于间充质干细胞的镇痛治疗的优化策略：疼痛管理有前景的治疗方法。
Stem Cell Res Ther. 2024 Jul 18;15(1):211. doi: 10.1186/s13287-024-03828-8.

本文引用的文献

1
Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury.水凝胶作为递送系统和支架在继发性脊髓损伤治疗中的研究进展
Front Bioeng Biotechnol. 2023 Jan 18;11:1111882. doi: 10.3389/fbioe.2023.1111882. eCollection 2023.
2
Therapeutic Effect of Biomimetic Scaffold Loaded with Human Amniotic Epithelial Cell-Derived Neural-like Cells for Spinal Cord Injury.负载人羊膜上皮细胞源性神经样细胞的仿生支架对脊髓损伤的治疗作用
Bioengineering (Basel). 2022 Oct 9;9(10):535. doi: 10.3390/bioengineering9100535.
3
Hydrogels in Spinal Cord Injury Repair: A Review.
水凝胶在脊髓损伤修复中的应用综述
Front Bioeng Biotechnol. 2022 Jun 21;10:931800. doi: 10.3389/fbioe.2022.931800. eCollection 2022.
4
Intravenous administration of human mesenchymal stem cells derived from adipose tissue and umbilical cord improves neuropathic pain via suppression of neuronal damage and anti-inflammatory actions in rats.静脉内给予源自脂肪组织和脐带的人间质干细胞通过抑制神经元损伤和发挥抗炎作用改善大鼠的神经病理性疼痛。
PLoS One. 2022 Feb 14;17(2):e0262892. doi: 10.1371/journal.pone.0262892. eCollection 2022.
5
Adipose Stem Cell-Based Treatments for Wound Healing.基于脂肪干细胞的伤口愈合治疗方法。
Front Cell Dev Biol. 2022 Jan 11;9:821652. doi: 10.3389/fcell.2021.821652. eCollection 2021.
6
Fabrication Techniques of Nerve Guidance Conduits for Nerve Regeneration.神经再生用神经导管的制作技术。
Yonsei Med J. 2022 Feb;63(2):114-123. doi: 10.3349/ymj.2022.63.2.114.
7
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease.八聚体结合转录因子4诱导的少突胶质前体细胞促进髓鞘再生并改善疾病。
NPJ Regen Med. 2022 Jan 13;7(1):4. doi: 10.1038/s41536-021-00199-z.
8
Angiogenic Effects and Crosstalk of Adipose-Derived Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles with Endothelial Cells.脂肪来源间充质干细胞/基质细胞及其细胞外囊泡与内皮细胞的血管生成作用及串扰。
Int J Mol Sci. 2021 Oct 8;22(19):10890. doi: 10.3390/ijms221910890.
9
Regenerative Medicine for Equine Musculoskeletal Diseases.马肌肉骨骼疾病的再生医学
Animals (Basel). 2021 Jan 19;11(1):234. doi: 10.3390/ani11010234.
10
Autologous fat grafting for nerve regeneration and neuropathic pain: current state from bench-to-bedside.自体脂肪移植在神经再生和神经病理性疼痛中的应用：从基础到临床的现状。
Regen Med. 2020 Oct;15(10):2209-2228. doi: 10.2217/rme-2020-0103. Epub 2020 Dec 2.