Lv Zhenshan, Dong Chao, Zhang Tianjiao, Zhang Shaokun
The Department of Spinal Surgery, 1st Hospital, Jilin University, Jilin Engineering Research Center for Spine and Spine Cord Injury, Changchun, China.
Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, China.
Front Bioeng Biotechnol. 2022 Jun 21;10:931800. doi: 10.3389/fbioe.2022.931800. eCollection 2022.
Traffic accidents and falling objects are responsible for most spinal cord injuries (SCIs). SCI is characterized by high disability and tends to occur among the young, seriously affecting patients' lives and quality of life. The key aims of repairing SCI include preventing secondary nerve injury, inhibiting glial scarring and inflammatory response, and promoting nerve regeneration. Hydrogels have good biocompatibility and degradability, low immunogenicity, and easy-to-adjust mechanical properties. While providing structural scaffolds for tissues, hydrogels can also be used as slow-release carriers in neural tissue engineering to promote cell proliferation, migration, and differentiation, as well as accelerate the repair of damaged tissue. This review discusses the characteristics of hydrogels and their advantages as delivery vehicles, as well as expounds on the progress made in hydrogel therapy (alone or combined with cells and molecules) to repair SCI. In addition, we discuss the prospects of hydrogels in clinical research and provide new ideas for the treatment of SCI.
交通事故和高空坠物是导致大多数脊髓损伤（SCI）的原因。脊髓损伤的特点是高致残率，且往往发生在年轻人中，严重影响患者的生活和生活质量。修复脊髓损伤的关键目标包括预防继发性神经损伤、抑制胶质瘢痕形成和炎症反应，以及促进神经再生。水凝胶具有良好的生物相容性和可降解性、低免疫原性以及易于调节的机械性能。在为组织提供结构支架的同时，水凝胶还可作为神经组织工程中的缓释载体，以促进细胞增殖、迁移和分化，并加速受损组织的修复。本文综述讨论了水凝胶的特性及其作为递送载体的优势，并阐述了水凝胶疗法（单独或与细胞和分子联合使用）在修复脊髓损伤方面取得的进展。此外，我们还讨论了水凝胶在临床研究中的前景，并为脊髓损伤的治疗提供新思路。
