Department of Obstetrics & Gynecology, Midwifery, Reproductive Health Research Center, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
PLoS One. 2022 Aug 15;17(8):e0271068. doi: 10.1371/journal.pone.0271068. eCollection 2022.
Body composition as dynamic indices constantly changes in pregnancy. The use of body composition indices in the early stages of pregnancy has recently been considered. Therefore, the current meta-analysis study was conducted to investigate the relationship between body composition in the early stages of pregnancy and gestational diabetes.
Valid databases searched for papers published from 2010 to December 2021 were based on PRISMA guideline. Newcastle Ottawa was used to assess the quality of the studies. For all analyses, STATA 14.0 was used. Mean difference (MD) of anthropometric indices was calculated between the GDM and Non-GDM groups. Pooled MD was estimated by "Metan" command, and heterogeneity was defined using Cochran's Q test of heterogeneity, and I 2 index was used to quantify heterogeneity.
Finally, 29 studies with a sample size of 56438 met the criteria for entering the meta-analysis. Pooled MD of neck circumference, hip circumference, waist hip ratio, and visceral adipose tissue depth were, respectively, 1.00 cm (95% CI: 0.79 to 1.20) [N = 5; I^2: 0%; p: 0.709], 7.79 cm (95% CI: 2.27 to 13.31) [N = 5; I2: 84.3%; P<0.001], 0.03 (95% CI: 0.02 to 0.04) [N = 9; I2: 89.2%; P<0.001], and 7.74 cm (95% CI: 0.11 to 1.36) [N = 4; I^2: 95.8%; P<0.001].
Increased neck circumference, waist circumference, hip circumference, arm circumference, waist to hip ratio, visceral fat depth, subcutaneous fat depth, and short stature increased the possibility of developing gestational diabetes. These indices can accurately, cost-effectively, and affordably assess the occurrence of gestational diabetes, thus preventing many consequences with early detection of gestational diabetes.
人体成分作为动态指标，在妊娠期间不断变化。最近，人们开始考虑在妊娠早期使用人体成分指标。因此，进行了本次荟萃分析研究，以调查妊娠早期人体成分与妊娠期糖尿病之间的关系。
根据 PRISMA 指南，检索了从 2010 年至 2021 年 12 月发表的有效数据库。使用纽卡斯尔-渥太华量表评估研究质量。对于所有分析，使用 STATA 14.0 进行。在 GDM 和非 GDM 组之间计算了人体测量学指标的均数差 (MD)。使用“Metan”命令估计汇总 MD，并使用 Cochran's Q 检验异质性定义，并用 I 2 指数量化异质性。
最终，有 29 项研究，样本量为 56438 人，符合纳入荟萃分析的标准。颈围、臀围、腰臀比和内脏脂肪组织深度的汇总 MD 分别为 1.00 cm（95%CI：0.79 至 1.20）[N=5；I^2：0%；p：0.709]、7.79 cm（95%CI：2.27 至 13.31）[N=5；I2：84.3%；P<0.001]、0.03（95%CI：0.02 至 0.04）[N=9；I2：89.2%；P<0.001]和 7.74 cm（95%CI：0.11 至 1.36）[N=4；I^2：95.8%；P<0.001]。
颈围、腰围、臀围、臂围、腰臀比、内脏脂肪深度、皮下脂肪深度和矮小增加了患妊娠期糖尿病的可能性。这些指标可以准确、经济有效地评估妊娠期糖尿病的发生，从而通过早期发现妊娠期糖尿病预防许多后果。
