Sun Xiangyu, Xu Chengshi, Cai Yuxiang, Pan Zhiyong, Li Zhiqiang
Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430062, China.
Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430062, China.
Brain Sci. 2023 May 11;13(5):786. doi: 10.3390/brainsci13050786.
Meningioangiomatosis (MA) is a rare hamartomatous or meningovascular lesion involving the central nervous system, and is sometimes associated with intracranial meningiomas. Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare, slow-growing benign tumor-like lesions that can occur anywhere along the neuraxis. Here, we report a rare case of MA combined with CAPNON. A 31-year-old woman was admitted to our hospital because of a high-density mass in the left frontal lobe, detected by computed tomography (CT) during a physical examination. She had a 3-year history of obsessive-compulsive disorder. We describe the imaging, histopathological, and molecular characteristics of the patient. To our knowledge, this is the first report describing MA combined with CAPNON. We reviewed the literature on MA and CAPNON over the last decade and summarized the points for differential diagnosis and treatment. It is difficult to preoperatively distinguish between MA and CAPNON. However, this coexisting condition should be considered when intra-axial calcification lesions are observed on radiological imaging. Accurate diagnosis and appropriate treatment are likely to benefit this patient group.
脑膜血管外皮细胞瘤（MA）是一种罕见的错构瘤或脑膜血管病变，累及中枢神经系统，有时与颅内脑膜瘤相关。神经轴索钙化性假瘤（CAPNON）是罕见的、生长缓慢的良性肿瘤样病变，可发生于神经轴索的任何部位。在此，我们报告1例罕见的MA合并CAPNON病例。一名31岁女性因体检时计算机断层扫描（CT）发现左额叶高密度肿块入住我院。她有3年强迫症病史。我们描述了该患者的影像学、组织病理学和分子特征。据我们所知，这是第一篇描述MA合并CAPNON的报告。我们回顾了过去十年关于MA和CAPNON的文献，并总结了鉴别诊断和治疗要点。术前很难区分MA和CAPNON。然而，当在放射影像学上观察到轴内钙化病变时，应考虑这种共存情况。准确的诊断和适当的治疗可能使该患者群体受益。
