Van Winkle T J, Balk M W
Lab Anim Sci. 1986 Jun;36(3):248-55.
Corneal opacities were observed in numerous strains and stocks of laboratory mice (Mus musculus) from different microbiological environments. The opacities were characterized as acute and chronic inflammatory lesions of the corneal epithelium and anterior corneal stroma, including corneal ulcers and erosions, acute keratitis, stromal neovascularization and mineralization of the basement membrane zone. Some strains and stocks of mice from barrier-reared colonies had a high incidence of corneal opacities [DBA/2 (29.1%), C3H (16.2%), CF1 (16.2%) and BALB/c (10.0%)] while others had a lower incidence [CD-1 (4.3%) and C57BL/6 (4.1%)]. Axenic and gnotobiotic mice had a very low incidence of corneal opacities (1.6%). An experimental study demonstrated that twice weekly cage cleaning would reduce the incidence of corneal opacities to a very low level. A bacterial product, such as ammonia, is proposed as a significant factor in the pathogenesis of spontaneous corneal opacities in laboratory mice.
在来自不同微生物环境的众多实验室小鼠（小家鼠）品系和种群中观察到角膜混浊。这些混浊被表征为角膜上皮和角膜前基质的急性和慢性炎性病变，包括角膜溃疡和糜烂、急性角膜炎、基质新生血管形成以及基底膜区矿化。来自屏障饲养群落的一些小鼠品系和种群角膜混浊发生率较高[DBA/2（29.1%）、C3H（16.2%）、CF1（16.2%）和BALB/c（10.0%）]，而其他品系和种群发生率较低[CD-1（4.3%）和C57BL/6（4.1%）]。无菌和悉生小鼠角膜混浊发生率非常低（1.6%）。一项实验研究表明，每周两次清洁笼子可将角膜混浊发生率降低到非常低的水平。一种细菌产物，如氨，被认为是实验室小鼠自发性角膜混浊发病机制中的一个重要因素。
