Wistar Hannover大鼠的角膜矿化

Corneal mineralization in wistar hannover rats.

作者信息

Hashimoto Satomi, Doi Takuya, Wako Yumi, Sato Junko, Wada Sou, Tsuchitani Minoru

机构信息

Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan.

出版信息

J Toxicol Pathol. 2013 Sep;26(3):275-81. doi: 10.1293/tox.26.275. Epub 2013 Oct 15.

DOI:10.1293/tox.26.275

PMID:24155560

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3787605/

Abstract

We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ultrastructurally investigated. According to the results, Wistar Hannover rats had a much higher incidence of corneal mineralization compared with Sprague-Dawley rats. The incidence of corneal mineralization was higher in males than females. According to the histological examination, mineral deposits were positive for calcium by von Kossa's method. Furthermore, in response to mineralization, keratocytes probably become active to play an important role against the mineralized substance.

摘要

我们最近在日本开始使用Wistar Hannover大鼠，目前正在收集背景数据。我们经常在RccHan(TM):WIST和Crl:WI (Han)品系的Wistar Hannover大鼠中观察到角膜矿化现象。在本研究中，对Wistar Hannover大鼠角膜矿化的细节进行了组织病理学和超微结构研究。结果显示，与Sprague-Dawley大鼠相比，Wistar Hannover大鼠角膜矿化的发生率要高得多。角膜矿化的发生率男性高于女性。根据组织学检查，用冯·科萨氏法检测矿化沉积物对钙呈阳性反应。此外，针对矿化反应，角膜细胞可能会变得活跃，对矿化物质发挥重要作用。