Bellin Michael A, Reitnauer Kyle J, Gomez Amber M, Lee-Stubbs Robyn B, Ruff Albert L
Veterinary Medicine and Surgery Department, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA.
Laboratory Services Department, Research Support Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA.
J Am Assoc Lab Anim Sci. 2019 Mar 1;58(2):154-159. doi: 10.30802/AALAS-JAALAS-18-000075. Epub 2019 Feb 25.
This study compared a synthetic bedding substrate (SBS), which has the potential to be a particulate-free animal bedding system, with the standard woodchip bedding. The objective was to demonstrate that the SBS is habitable for mice and reduces particulates to levels that would not contaminate the eye or potentially induce ocular (corneal) injury. Newly weaned mice were placed in either standard woodchip bedding or SBS. All mice were monitored regarding overall health (appearance, food and water intake, natural behavior, clinical signs, and provoked behavior) to verify their ability to adjust to the bedding. At 8 to 10 wk of age, the mice underwent slit-lamp evaluation for ocular (corneal) abnormalities. Results showed significant differences in body weight and overall health between bedding groups. The incidence of ocular abnormalities did not differ significantly between groups. We conclude that, without modifications and more testing, SBS is not a favorable bedding for mice, and results were inconclusive regarding its use as a bedding to preclude ocular contamination.
本研究将一种有可能成为无颗粒动物垫料系统的合成垫料基质（SBS）与标准木屑垫料进行了比较。目的是证明SBS适合小鼠居住，并将颗粒减少到不会污染眼睛或潜在诱发眼部（角膜）损伤的水平。刚断奶的小鼠被置于标准木屑垫料或SBS中。对所有小鼠的整体健康状况（外观、食物和水摄入量、自然行为、临床症状和激发行为）进行监测，以验证它们适应垫料的能力。在8至10周龄时，对小鼠进行裂隙灯检查以评估眼部（角膜）异常情况。结果显示垫料组之间的体重和整体健康状况存在显著差异。两组之间眼部异常的发生率没有显著差异。我们得出结论，在未经改进和更多测试的情况下，SBS不是适合小鼠的垫料，关于其作为防止眼部污染的垫料的使用结果尚无定论。
