Chien Tsuo-Hsuan, Lin Chih-Lang, Chen Li-Wei, Chien Cheng-Hung, Hu Ching-Chih
Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, Keelung Branch, Keelung 204, Taiwan.
Community Medicine Research Center, Chang-Gung Memorial Hospital and University, Keelung Branch, Keelung 204, Taiwan.
J Pers Med. 2023 Apr 28;13(5):758. doi: 10.3390/jpm13050758.
Patients with non-alcoholic fatty liver disease (NAFLD) share similar pathophysiologies to those of patients with alcohol liver disease. Alcoholic metabolic enzyme-related genes (alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2)) may be associated with pathophysiology in NAFLD patients. In this study, the association between ADH1B/ALDH2 gene polymorphism and serum metabolic factors, body statures, and hepatic steatosis/fibrosis status was evaluated in patients with NAFLD. Using biochemistry data, abdominal ultrasonography, fibrosis evaluation (Kpa), and steatosis evaluation (CAP), ADH1B gene SNP rs1229984 and ALDH2 gene SNP rs671 polymorphism were analyzed in sixty-six patients from 1 January 2022 to 31 December 2022. The percentage of the mutant type (GA + AA) was 87.9% (58/66) in the ADH1B allele and 45.5% (30/66) in the ALDH2 allele. Patients with the mutant-type ADH1B/ALDH2 allele had higher values of alanine aminotransferase (ALT) than the wild type (β = 0.273, = 0.04). No association was observed between body mass index, serum metabolic factors (sugar and lipid profile), CAP, kPa, and ADH1B/ALDH2. A high proportion of the mutant-type ADH1B allele (87.9%) and ALDH2 allele (45.5%) was observed in patients with NAFLD. No association was observed between ADH1B/ALDH2 allele, BMI, and hepatic steatosis/fibrosis. Patients with the mutant-type ADH1B/ALDH2 allele had higher values of ALT than those with the wild type.
非酒精性脂肪性肝病（NAFLD）患者与酒精性肝病患者具有相似的病理生理学特征。酒精代谢酶相关基因（酒精脱氢酶1B（ADH1B）和乙醛脱氢酶2（ALDH2））可能与NAFLD患者的病理生理学相关。在本研究中，评估了NAFLD患者中ADH1B/ALDH2基因多态性与血清代谢因子、身体状况以及肝脂肪变性/纤维化状态之间的关联。利用生化数据、腹部超声、纤维化评估（Kpa）和脂肪变性评估（CAP），对2022年1月1日至2022年12月31日期间的66例患者的ADH1B基因单核苷酸多态性（SNP）rs1229984和ALDH2基因SNP rs671多态性进行了分析。ADH1B等位基因中突变型（GA + AA）的比例为87.9%（58/66），ALDH2等位基因中为45.5%（30/66）。具有ADH1B/ALDH2等位基因突变型的患者丙氨酸氨基转移酶（ALT）值高于野生型（β = 0.273，P = 0.04）。未观察到体重指数、血清代谢因子（糖和脂质谱）、CAP、kPa与ADH1B/ALDH2之间存在关联。在NAFLD患者中观察到高比例的ADH1B等位基因突变型（87.9%）和ALDH2等位基因突变型（45.5%）。未观察到ADH1B/ALDH2等位基因、BMI与肝脂肪变性/纤维化之间存在关联。具有ADH1B/ALDH2等位基因突变型的患者ALT值高于野生型患者。
