Hao Xiaoyan, Zeng Qiang
Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Dec 22;13:5049-5057. doi: 10.2147/DMSO.S290491. eCollection 2020.
This study investigated the association between the polymorphism, food group intake, and the probability of having non-alcoholic fatty liver disease (NAFLD) in a Chinese population.
A total of 3506 adults were enrolled in this study, and all underwent physical examinations and genotyping of polymorphisms with polymerase chain reaction. Participants filled out a dietary questionnaire that was used to assess the frequency and quantity of food consumption.
We found that milk groups were associated with a lower probability of developing NAFLD. On the contrary, meat and salted and smoked foods were associated with a higher probability of NAFLD. However, the influences of salted and smoked foods and fresh fruit and vegetables on NAFLD were obviously different in the two genotype groups. Salted and smoked foods intake was a factor associated with a higher probability of having NAFLD or nonalcoholic steatohepatitis (NASH) in the A genotype group, but there was no effect in the G genotype group. Moreover, eating salted and smoked foods several times per week was associated with a higher probability of having NAFLD than seldom consuming them. Consumption of fresh fruit and vegetables was not a factor influencing the probability of having NAFLD in the A genotype group, and there was no effect in the G genotype group. Further analysis of the interaction indicated that the GA +AA genotype showed an interaction with fresh fruit and vegetables and salted and smoked foods. Moreover, it was not obvious that meat intake increased the probability of having NAFLD or NASH among different genotypes.
Our results indicate that GA and AA genotypes are factors associated with increased probability of NAFLD among Chinese subjects. This could stimulate the development of novel approaches for preventing NAFLD.
本研究调查了中国人群中基因多态性、食物组摄入量与非酒精性脂肪性肝病（NAFLD）患病概率之间的关联。
本研究共纳入3506名成年人，所有参与者均接受了体格检查，并采用聚合酶链反应进行基因多态性基因分型。参与者填写了一份饮食问卷，用于评估食物消费的频率和数量。
我们发现奶类食物组与患NAFLD的概率较低相关。相反，肉类以及腌制和烟熏食品与患NAFLD的概率较高相关。然而，在两个基因型组中，腌制和烟熏食品以及新鲜水果和蔬菜对NAFLD的影响明显不同。在A基因型组中，摄入腌制和烟熏食品是与患NAFLD或非酒精性脂肪性肝炎（NASH）概率较高相关的一个因素，但在G基因型组中则没有影响。此外，每周食用几次腌制和烟熏食品比很少食用这些食品的人患NAFLD的概率更高。在A基因型组中，食用新鲜水果和蔬菜不是影响患NAFLD概率的因素，在G基因型组中也没有影响。进一步的交互作用分析表明，GA+AA基因型与新鲜水果和蔬菜以及腌制和烟熏食品之间存在交互作用。此外，在不同基因型中，肉类摄入增加患NAFLD或NASH的概率并不明显。
我们的结果表明，GA和AA基因型是中国人群中与NAFLD患病概率增加相关的因素。这可能会促进预防NAFLD新方法的开发。
