Mäkilä Eeva, Ekblad Mikael O, Rautava Päivi, Lapinleimu Helena, Setänen Sirkku
Department of Pediatric Neurology, University of Turku, 20014 Turku, Finland.
Salo Health Centre, 24240 Salo, Finland.
J Pers Med. 2023 May 12;13(5):819. doi: 10.3390/jpm13050819.
Children born very preterm have increased risk of developmental difficulties. We examined the parental perception of developmental profile of children born very preterm at 5 and 8 years by using the parental questionnaire Five-to-Fifteen (FTF) compared to full-term controls. We also studied the correlation between these age points. The study included 168 and 164 children born very preterm (gestational age < 32 weeks and/or birth weight ≤ 1500 g) and 151 and 131 full-term controls. The rate ratios (RR) were adjusted for sex and the father's educational level. At 5 and 8 years, children born very preterm were more likely to have higher scores (more difficulties) compared to controls in motor skills (RR = 2.3, CI 95% = 1.8-3.0 at 5 years and RR = 2.2, CI 95% = 1.7-2.9 at 8 years), executive function (1.7, 1.3-2.2 and 1.5, 1.2-2.0), perception (1.9, 1.4-2.5 and 1.9, 1.5-2.5), language (1.5, 1.1-1.9 and 2.2, 1.7-2.9), and social skills (1.4, 1.1-1.8 and 2.1, 1.6-2.7), and at 8 years in learning (1.9, 1.4-2.6) and memory (1.5, 1.2-2.0). There were moderate-to-strong correlations (r = 0.56-0.76, < 0.001) in all domains between 5 and 8 years in children born very preterm. Our findings suggest that FTF might help to earlier identify children at the greatest risk of incurring developmental difficulties persisting to school-age.
极早产儿出现发育困难的风险增加。我们通过使用父母问卷“5至15岁儿童发育情况问卷”（FTF），比较了极早产儿与足月儿对照在5岁和8岁时父母对其发育状况的认知。我们还研究了这两个年龄点之间的相关性。该研究纳入了168名和164名极早产儿（胎龄<32周和/或出生体重≤1500克）以及151名和131名足月儿对照。比率比（RR）根据性别和父亲的教育水平进行了调整。在5岁和8岁时，与对照组相比，极早产儿在运动技能（5岁时RR = 2.3，95%CI = 1.8 - 3.0；8岁时RR = 2.2，95%CI = 1.7 - 2.9）、执行功能（1.7，1.3 - 2.2和1.5，1.2 - 2.0）、感知（1.9，1.4 - 2.5和1.9，1.5 - 2.5）、语言（1.5，1.1 - 1.9和2.2，1.7 - 2.9）以及社交技能（1.4，1.1 - 1.8和2.1，1.6 - 2.7）方面更有可能得分更高（即困难更多），并且在8岁时在学习（1.9，1.4 - 2.6）和记忆（1.5，1.2 - 2.0）方面也是如此。极早产儿在5岁至8岁的所有领域中存在中度至高度相关性（r = 0.56 - 0.76，<0.001）。我们的研究结果表明，FTF可能有助于更早地识别出持续到学龄期出现发育困难风险最大的儿童。
