Yang Meiqing, Wang Lu, Lu Haozi, Dong Qizhi
Zoology Key Laboratory of Hunan Higher Education, College of Life and Environmental Science, Hunan University of Arts and Science, Changde 415000, China.
Institute of Chemical Biology and Nanomedicine (ICBN), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Micromachines (Basel). 2023 May 21;14(5):1088. doi: 10.3390/mi14051088.
Neurotransmitters are chemical messengers that play an important role in the nervous system's control of the body's physiological state and behaviour. Abnormal levels of neurotransmitters are closely associated with some mental disorders. Therefore, accurate analysis of neurotransmitters is of great clinical importance. Electrochemical sensors have shown bright application prospects in the detection of neurotransmitters. In recent years, MXene has been increasingly used to prepare electrode materials for fabricating electrochemical neurotransmitter sensors due to its excellent physicochemical properties. This paper systematically introduces the advances in MXene-based electrochemical (bio)sensors for the detection of neurotransmitters (including dopamine, serotonin, epinephrine, norepinephrine, tyrosine, NO, and HS), with a focus on their strategies for improving the electrochemical properties of MXene-based electrode materials, and provides the current challenges and future prospects for MXene-based electrochemical neurotransmitter sensors.
神经递质是化学信使,在神经系统控制身体生理状态和行为方面发挥着重要作用。神经递质水平异常与一些精神障碍密切相关。因此,准确分析神经递质具有重要的临床意义。电化学传感器在神经递质检测中展现出了广阔的应用前景。近年来,由于其优异的物理化学性质,MXene越来越多地被用于制备用于制造电化学神经递质传感器的电极材料。本文系统介绍了基于MXene的用于检测神经递质(包括多巴胺、血清素、肾上腺素、去甲肾上腺素、酪氨酸、一氧化氮和硫化氢)的电化学(生物)传感器的进展,重点介绍了它们改善基于MXene的电极材料电化学性质的策略,并阐述了基于MXene的电化学神经递质传感器当前面临的挑战和未来前景。