Beijing Advanced Innovation Center for Materials Genome Engineering, Collaborative Innovation Center of Steel Technology, University of Science and Technology Beijing, Beijing 100083, China.
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Dalton Trans. 2022 Mar 15;51(11):4549-4559. doi: 10.1039/d2dt00110a.
Dopamine (DA), uric acid (UA) and ascorbic acid (AA) are biomolecules widely distributed in the human body and play an important role in many physiological processes. An abnormal concentration of them is associated with various diseases. Thus, the accurate and fast detection of them has been one of the major demands in the healthcare industry. In this study, we demonstrate that TiCT/PtNP modified glassy carbon electrodes (GCEs) show a good electrochemical performance in the detection of DA and UA. However, there is no response signal to AA for either the CV or DPV curve due to the electrostatic repulsion between the negatively charged electrode surface and the negatively charged AA. TiCT(MXene)/Pt nanoparticles (PtNPs) are prepared by etching TiAlC(MAX) with HF and reducing HPtCl with a NaBH aqueous solution. The morphology of TiCT/PtNPs is multilayered accordion-like TiCT decorated with PtNPs with a diameter of 10-20 nm. Furthermore, it is found that the electrochemical detection of DA will be enhanced by AA. The electrochemical detection rule of AA enhanced DA can be expressed as follows: = 0.011216 + 0.039950 + 1.1175( is the peak current of DA coexisting with AA. is the concentration of AA. is the concentration of DA). This can be used as a calibration to correct the concentration of DA when AA and DA coexist. Notably, AA promotes the stability of the electrode because it cleans the oxidation products from the electrode surface in time. In addition, the sensor exhibits good reproducibility and satisfactory recovery results in a real sample.
多巴胺（DA）、尿酸（UA）和抗坏血酸（AA）是广泛分布于人体中的生物分子，在许多生理过程中发挥着重要作用。它们的浓度异常与各种疾病有关。因此，准确、快速地检测它们一直是医疗保健行业的主要需求之一。在本研究中，我们证明 TiCT/PtNP 修饰的玻碳电极（GCE）在检测 DA 和 UA 方面表现出良好的电化学性能。然而，无论是 CV 还是 DPV 曲线，对于 AA 都没有响应信号，这是由于带负电荷的电极表面与带负电荷的 AA 之间的静电排斥。TiCT（MXene）/Pt 纳米颗粒（PtNPs）是通过用 HF 刻蚀 TiAlC（MAX）并用 NaBH4 水溶液还原 HPtCl 制备的。TiCT/PtNPs 的形态是多层褶皱状的 TiCT 被 10-20nm 直径的 PtNPs 修饰。此外，研究发现 AA 会增强 DA 的电化学检测。AA 增强 DA 的电化学检测规律可表示为： = 0.011216 + 0.039950 + 1.1175（是存在 AA 时 DA 的峰电流。 是 AA 的浓度。 是 DA 的浓度）。这可以用作校正 AA 和 DA 共存时 DA 浓度的校准。值得注意的是，AA 提高了电极的稳定性，因为它及时从电极表面清除了氧化产物。此外，该传感器具有良好的重现性和令人满意的回收率，可用于实际样品分析。
