Hasatsri Sukhontha, Suthi Jariya, Siriwut Nattaporn, Charoensappakit Onjira
Department of Pharmacy Practice, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand.
Sunpasitthiprasong Hospital, Ubon Ratchathani 34000, Thailand.
Pharmaceuticals (Basel). 2023 May 2;16(5):685. doi: 10.3390/ph16050685.
has several biological activities, including antibacterial and anti-inflammatory activities, that improve wound healing. It is well known that physical properties and pH environment are crucial considerations when developing wound dressings containing medicinal plant extracts in order to create an appropriate environment for wound healing. In this study, we prepared a foam dressing containing leaf extract and gelatin. Chemical composition was verified using Fourier-transform infrared spectroscopy (FTIR) and pore structure was obtained using scanning electron microscopy (SEM). The physical properties of the dressing, including absorption and dehydration properties, were also evaluated. The chemical properties were measured to determine the pH environment after the dressing was suspended in water. The results revealed that the dressings had a pore structure with an appropriate pore size (313.25 ± 76.51 µm and 383.26 ± 64.45 µm for the A and B dressings, respectively). The B dressings showed a higher percentage of weight increase in the first hour and a faster dehydration rate in the first 4 h. Furthermore, the dressings had a slightly acidic environment (5.28 ± 0.02 and 5.38 ± 0.02 for the A and B dressings at 48 h, respectively).
具有多种生物活性，包括抗菌和抗炎活性，可促进伤口愈合。众所周知，在开发含有药用植物提取物的伤口敷料时，物理性质和pH环境是关键考虑因素，以便为伤口愈合创造适宜的环境。在本研究中，我们制备了一种含有叶提取物和明胶的泡沫敷料。使用傅里叶变换红外光谱（FTIR）验证化学成分，并使用扫描电子显微镜（SEM）获得孔隙结构。还评估了敷料的物理性质，包括吸收和脱水性质。测量化学性质以确定敷料悬浮在水中后的pH环境。结果显示，敷料具有孔径合适的孔隙结构（A敷料和B敷料的孔径分别为313.25±76.51μm和383.26±64.45μm）。B敷料在第1小时的重量增加百分比更高，在前4小时的脱水速率更快。此外，敷料具有略呈酸性的环境（48小时时，A敷料和B敷料的pH分别为5.28±0.02和5.38±0.02）。
