在哈萨克斯坦南部的小菊头蝠中发现的一种新型腺病毒的检测和系统发育特征。

Detection and Phylogenetic Characterization of a Novel Adenovirus Found in Lesser Mouse-Eared Bat () in South Kazakhstan.

机构信息

Scientific Production Center of Microbiology and Virology, 105 Bogenbay Batyr Str., Almaty A25K1G0, Kazakhstan.

出版信息

Viruses. 2023 May 10;15(5):1139. doi: 10.3390/v15051139.

DOI:10.3390/v15051139

PMID:37243225

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10224130/

Abstract

Bats are an important natural reservoir of various pathogenic microorganisms, and regular monitoring is necessary to track the situation of zoonotic infections. When examining samples from bats in South Kazakhstan, nucleotide sequences of putative novel bat adenovirus (AdV) species were found. Estimates of amino acid identities of the hexon protein have shown that potentially novel Bat mastadenovirus BatAdV-KZ01 shared higher similarity with monkey Rhesus adenovirus 59 (74.29%) than with Bat AdVs E and H (74.00%). Phylogenetically, BatAdV-KZ01 formed a separate clade, distant from Bat AdVs and other mammalian AdVs. Since adenoviruses are essential pathogens for many mammals, including humans and bats, this finding is of interest from both scientific and epidemiological points of view.

摘要

蝙蝠是多种病原微生物的重要天然宿主，为了跟踪人畜共患病感染的情况，需要定期对蝙蝠进行监测。在对哈萨克斯坦南部的蝙蝠样本进行检查时，发现了一些可能是新型蝙蝠腺病毒（AdV）的核苷酸序列。对六邻体蛋白的氨基酸同一性的估计表明，潜在的新型蝙蝠巨细胞病毒 BatAdV-KZ01 与猴猴腺病毒 59（74.29%）的相似度高于蝙蝠 AdVs E 和 H（74.00%）。系统发育分析表明，BatAdV-KZ01 与蝙蝠 AdVs 和其他哺乳动物 AdVs 形成了一个单独的分支。由于腺病毒是许多哺乳动物（包括人类和蝙蝠）的重要病原体，因此从科学和流行病学的角度来看，这一发现都具有重要意义。