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CTLA-4 在慢性乙型肝炎病毒感染中 T 细胞耗竭的作用。

The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection.

机构信息

Department of Infectious Diseases, Copenhagen University Hospital, 2650 Hvidovre, Denmark.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

出版信息

Viruses. 2023 May 10;15(5):1141. doi: 10.3390/v15051141.

DOI:10.3390/v15051141
PMID:37243227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10223466/
Abstract

Patients with chronic hepatitis B (CHB) gradually develop T cell exhaustion, and the inhibitory receptor molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), may play a role in this phenomenon. This systematic review investigates the role of CTLA-4 in the development of T cell exhaustion in CHB. A systematic literature search was conducted on PubMed and Embase on 31 March 2023 to identify relevant studies. Fifteen studies were included in this review. A majority of the studies investigating CD8 T cells demonstrated increased expression of CTLA-4 in CHB patients, though one study found this only in HBeAg-positive patients. Three out of four studies investigating the expression of CTLA-4 on CD4 T cells found upregulation of CTLA-4. Several studies showed constitutive expression of CLTA-4 on CD4 regulatory T cells. CTLA-4 blockade resulted in heterogeneous responses for all T cell types, as it resulted in increased T cell proliferation and/or cytokine production in some studies, while other studies found this only when combining blockade of CTLA-4 with other inhibitory receptors. Although mounting evidence supports a role of CTLA-4 in T cell exhaustion, there is still insufficient documentation to describe the expression and exact role of CTLA-4 in T cell exhaustion in CHB.

摘要

慢性乙型肝炎 (CHB) 患者的 T 细胞逐渐衰竭，而细胞毒性 T 淋巴细胞抗原-4 (CTLA-4) 等抑制性受体分子可能在此现象中发挥作用。本系统评价旨在研究 CTLA-4 在 CHB 患者 T 细胞衰竭中的作用。本研究于 2023 年 3 月 31 日在 PubMed 和 Embase 上进行了系统文献检索，以确定相关研究。本综述纳入了 15 项研究。大多数研究发现 CD8 T 细胞中 CTLA-4 的表达增加，尽管有一项研究仅在 HBeAg 阳性患者中发现了这一点。四项研究中，有三项研究发现 CD4 T 细胞上 CTLA-4 的表达上调。几项研究显示 CD4 调节性 T 细胞上 CTLA-4 的组成性表达。CTLA-4 阻断对所有 T 细胞类型的反应均不同，因为在一些研究中，CTLA-4 阻断导致 T 细胞增殖和/或细胞因子产生增加，而其他研究仅在 CTLA-4 阻断与其他抑制性受体联合阻断时发现这一点。尽管越来越多的证据支持 CTLA-4 在 T 细胞衰竭中的作用，但仍缺乏足够的证据来描述 CTLA-4 在 CHB 患者 T 细胞衰竭中的表达和确切作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a0/10223466/32b510c0d16a/viruses-15-01141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a0/10223466/83f4729b156c/viruses-15-01141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a0/10223466/32b510c0d16a/viruses-15-01141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a0/10223466/83f4729b156c/viruses-15-01141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a0/10223466/32b510c0d16a/viruses-15-01141-g002.jpg

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