肿瘤微环境胆固醇图谱为改善 CAR-T 疗法提供了途径。
Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy.
机构信息
Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany; Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 1524, São Paulo 05508000, Brazil.
Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
出版信息
Cancer Cell. 2023 Jul 10;41(7):1204-1206. doi: 10.1016/j.ccell.2023.05.013. Epub 2023 May 26.
Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell exhaustion by inhibiting mTORC1 signaling. Moreover, they demonstrate that increasing cholesterol levels in chimeric antigen receptor (CAR)-T cells by blocking liver X receptor (LXR) leads to improved anti-tumor function.
胆固醇对于细胞毒性 T 细胞消除癌细胞的能力至关重要。在本期《癌细胞》杂志中，Yan 等人揭示了肿瘤内胆固醇缺乏如何通过抑制 mTORC1 信号通路导致 T 细胞耗竭。此外，他们还证明通过阻断肝 X 受体（LXR）来增加嵌合抗原受体（CAR）-T 细胞中的胆固醇水平可提高抗肿瘤功能。
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