Bile Salts by the Back Road.
作者信息
Oude Elferink Ronald P J, Van De Graaf Stan F J
机构信息
Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Research Institute AGEM, University of Amsterdam, Amsterdam, the Netherlands.
Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Research Institute AGEM, University of Amsterdam, Amsterdam, the Netherlands.
出版信息
Cell Mol Gastroenterol Hepatol. 2023;16(2):319-320. doi: 10.1016/j.jcmgh.2023.05.005. Epub 2023 May 24.
Abstract
摘要
相似文献
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Cell Mol Gastroenterol Hepatol. 2023;16(2):319-320. doi: 10.1016/j.jcmgh.2023.05.005. Epub 2023 May 24.
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本文引用的文献
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Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans.有机阴离子转运多肽 1B3（OATP1B3）是人类肝脏摄取结合胆汁酸的重要转运体。
Cell Mol Gastroenterol Hepatol. 2023;16(2):223-242. doi: 10.1016/j.jcmgh.2023.04.007. Epub 2023 May 3.
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Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes.转子综合征：肝细胞再摄取缺陷导致的结合胆汁酸血症。
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Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency.在牛磺胆酸钠共转运多肽缺乏的小鼠和人类受试者中，胆汁酸的硫酸化增加。
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Kinetic characterization of bile salt transport by human NTCP (SLC10A1).人钠离子依赖性胆盐转运体（SLC10A1）的胆汁盐转运动力学特征。
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Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice.在小鼠中，结合型胆汁酸的肝脏摄取由牛磺胆酸钠共转运多肽和有机阴离子转运多肽介导，并受血浆胆汁酸水平的肠道感知调节。
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6
Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3.与未结合胆汁酸相比，结合胆汁酸作为有机阴离子转运多肽1B1（OATP1B1）和有机阴离子转运多肽1B3（OATP1B3）底物的偏好性。
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Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype.牛磺胆酸钠共转运蛋白（SLC10A1）缺乏症：结合性高胆血症，无明显临床表型。
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Functions of OATP1A and 1B transporters in vivo: insights from mouse models.OATP1A 和 1B 转运体在体内的功能：来自小鼠模型的见解。
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Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.有机阴离子转运多肽 1a/1b 敲除小鼠为胆红素、胆汁酸和药物的肝脏处理提供了深入了解。
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Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans.SLCO1B1基因多态性对人体胆汁酸血浆浓度及胆汁酸合成标志物的影响。
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