State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China.
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China; School of Life Sciences, Hebei University, Hebei 071002, PR China.
Ecotoxicol Environ Saf. 2023 Jul 1;259:115065. doi: 10.1016/j.ecoenv.2023.115065. Epub 2023 May 26.
Agrochemical indoxacarb is an important tool for selective pest control in radish that be consumed globally. A rapid and sensitive analytical method UHPLC-MS/MS was developed for tracing indoxacarb in radish leaves and roots with LOQ of 0.001 mg/kg and RT within 2 min, which were confirmed the satisfied storage stability of indoxacarb in radish matrixes with degradation rates less than 30 %. The occurrence, pharmacokinetics dissipation and concentration variation of indoxacarb were reflected by the original deposition of 2.23-4.12 mg/kg, half-lives of 2.6-8.0 d and terminal magnitude of 0.17 × 10-25.46 mg/kg in radish, and the influencing factors were further illustrated in terms of climate factors, crop cultivars and soil properties. The highest residues of indoxacarb were 25.46 mg/kg in leaves and 0.12 mg/kg in roots, which were higher than international maximum residue limits. A probabilistic model, as well as deterministic model, were introduced to evaluated the health risks of indoxacarb offering a better description for uncertainty. The total chronic dietary risk values of indoxacarb were 146.961-482.065 % in 12 registered crops, of which ADI % in radish was accounted for 19.8 % with risk dilution effects. The unacceptable acute dietary risks of 121.358-220.331 % were observed at 99.9th percentile, whereas the high-potential non-carcinogenic effects were observed over 90th percentile (105.035-1121.943 %). The health risks should be continuously emphasized given the increasing applications and persistent characteristics of indoxacarb, which is vital to protect the human population from hazardous effects, particularly for vulnerable children.
农药茚虫威是一种用于全球消费的萝卜选择性害虫防治的重要工具。建立了一种快速灵敏的 UHPLC-MS/MS 分析方法，用于检测萝卜叶片和根部中的茚虫威，LOQ 为 0.001mg/kg，RT 为 2min，证实了茚虫威在萝卜基质中的降解率小于 30%，具有良好的储存稳定性。通过原始沉积量 2.23-4.12mg/kg、半衰期 2.6-8.0d 和末端量 0.17×10-25.46mg/kg，反映了茚虫威在萝卜中的发生、药代动力学消解和浓度变化，并进一步从气候因素、作物品种和土壤特性等方面说明了影响因素。萝卜叶片中茚虫威的最高残留量为 25.46mg/kg，根部为 0.12mg/kg，均高于国际最大残留限量。引入概率模型和确定性模型来评估茚虫威的健康风险，为不确定性提供了更好的描述。在 12 种已登记作物中，茚虫威的总慢性膳食风险值为 146.961%-482.065%，其中萝卜的 ADI%占 19.8%，具有风险稀释效应。在 99.9%分位数处观察到不可接受的急性膳食风险 121.358%-220.331%，而在 90%分位数以上观察到高潜在非致癌效应（105.035-1121.943%）。鉴于茚虫威的应用不断增加和持续存在，应持续强调健康风险，这对于保护人群免受有害影响至关重要，特别是对弱势儿童。
