Iakovleva E P, Alekseeva L E, Kuznetsova O S, Korshunov A I, Sukharevich V I
Mikrobiologiia. 1986 Mar-Apr;55(2):198-204.
The cultural broth of Candida tropicalis was shown to contain an active compound which stimulated the synthesis of levorin, a polyene antibiotic Succinic acid was found to stimulate the antibiotic synthesis. The stimulating effect of the active compound increased in proportion to the content of succinic acid in it and became maximal at the same concentration of succinic acid as in a pure preparation. However, succinic acid was not an only compound responsible for the elevated synthesis of the antibiotic since the biostimulating effect was higher than that of pure succinic acid.
热带假丝酵母的培养液被证明含有一种活性化合物,该化合物能刺激多烯抗生素制霉菌素的合成。发现琥珀酸能刺激抗生素的合成。活性化合物的刺激作用与其中琥珀酸的含量成正比增加,并在与纯制剂相同的琥珀酸浓度下达到最大值。然而,琥珀酸并不是导致抗生素合成增加的唯一化合物,因为生物刺激作用高于纯琥珀酸的刺激作用。