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1
Is the combination of oral midazolam and ketamine as preanesthetic medication a safe and effective practice?口服咪达唑仑和氯胺酮联合作为麻醉前用药是否安全有效？
Braz J Anesthesiol. 2023 Jul-Aug;73(4):370-372. doi: 10.1016/j.bjane.2023.05.004. Epub 2023 May 26.
2
Ketamine plus midazolam, a most effective paediatric oral premedicant.氯胺酮加咪达唑仑，一种极为有效的儿科口服术前用药。
Paediatr Anaesth. 1995;5(5):293-5. doi: 10.1111/j.1460-9592.1995.tb00307.x.
3
Four preanesthetic oral sedation protocols for rhesus macaques (Macaca mulatta).四种用于恒河猴（猕猴）的麻醉前口服镇静方案。
J Zoo Wildl Med. 2004 Dec;35(4):497-502. doi: 10.1638/03-092.
4
Evaluation of relatively low dose of oral transmucosal ketamine premedication in children: a comparison with oral midazolam.儿童口服黏膜下低剂量氯胺酮术前用药的评估：与口服咪达唑仑的比较。
Paediatr Anaesth. 2005 Aug;15(8):643-7. doi: 10.1111/j.1460-9592.2004.01513.x.
5
Combination of oral ketamine and midazolam as a premedication for a severely autistic and combative patient.口服氯胺酮与咪达唑仑联合用于一名重度自闭症且具有攻击性患者的术前用药。
J Anesth. 2009;23(1):126-8. doi: 10.1007/s00540-008-0685-4. Epub 2009 Feb 22.
6
Ketamine with and without midazolam for gastrointestinal endoscopies in children.氯胺酮联合咪达唑仑与单用氯胺酮在儿童胃肠内镜检查中的应用。
J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):748-52. doi: 10.1097/MPG.0b013e31824504af.
7
An allergic reaction following intramuscular administration of ketamine and midazolam.
J Clin Pediatr Dent. 2006 Winter;31(2):77-9. doi: 10.17796/jcpd.31.2.6q619k3664634250.
8
Oral preanesthetic medication in children ... comparison between midazolam alone and in combination with ketamine: a systematic review and meta-analysis.儿童口腔术前用药……咪达唑仑单用与联合氯胺酮的比较：系统评价和荟萃分析。
Braz J Anesthesiol. 2023 Jul-Aug;73(4):477-490. doi: 10.1016/j.bjane.2021.07.026. Epub 2021 Aug 16.
9
S(+)-ketamine for rectal premedication in children.S(+)-氯胺酮用于儿童直肠术前用药。
Anesth Analg. 2001 Jan;92(1):62-5. doi: 10.1097/00000539-200101000-00012.
10
Anaesthesia with medetomidine-ketamine-isoflurane with and without midazolam, in eight captive chimpanzees (Pan troglodytes) premedicated with oral zuclopenthixol.在八只口服珠氯噻醇进行预处理的圈养黑猩猩（黑猩猩属）中，使用美托咪定-氯胺酮-异氟烷并联合或不联合咪达唑仑进行麻醉。
Schweiz Arch Tierheilkd. 2013 Aug;155(8):471-6. doi: 10.1024/0036-7281/a000493.

引用本文的文献

1
A Narrative Review of the Efficacy and Safety of Oral Ketamine in Pediatric Sedation: A Critical Analysis of Current Evidence.口服氯胺酮用于小儿镇静的疗效与安全性的叙述性综述：对当前证据的批判性分析
Cureus. 2024 Aug 22;16(8):e67550. doi: 10.7759/cureus.67550. eCollection 2024 Aug.

本文引用的文献

1
The Perioperative Anesthetic Management of the Pediatric Patient with Special Needs: An Overview of Literature.特殊需求儿科患者的围手术期麻醉管理：文献综述
Children (Basel). 2022 Sep 21;9(10):1438. doi: 10.3390/children9101438.
2
Comparison between oral midazolam versus oral ketamine plus midazolam as preanesthetic medication in autism spectrum disorder: double-blind randomized clinical trial.口服咪达唑仑与口服氯胺酮加咪达唑仑作为自闭症谱系障碍患者术前用药的比较：双盲随机临床试验。
Braz J Anesthesiol. 2023 May-Jun;73(3):283-290. doi: 10.1016/j.bjane.2022.09.003. Epub 2022 Sep 29.
3
Serum concentration of oral midazolam as pediatric preanesthetic medication and factors related to the sedation level.口腔咪达唑仑作为小儿麻醉前用药的血清浓度与镇静水平相关因素。
Acta Anaesthesiol Scand. 2022 Aug;66(7):818-822. doi: 10.1111/aas.14077. Epub 2022 May 13.
4
Oral preanesthetic medication in children ... comparison between midazolam alone and in combination with ketamine: a systematic review and meta-analysis.儿童口腔术前用药……咪达唑仑单用与联合氯胺酮的比较：系统评价和荟萃分析。
Braz J Anesthesiol. 2023 Jul-Aug;73(4):477-490. doi: 10.1016/j.bjane.2021.07.026. Epub 2021 Aug 16.
5
Smartphone-based behavioural intervention alleviates children's anxiety during anaesthesia induction: A randomised controlled trial.基于智能手机的行为干预可减轻儿童麻醉诱导期的焦虑：一项随机对照试验。
Eur J Anaesthesiol. 2017 Mar;34(3):169-175. doi: 10.1097/EJA.0000000000000589.
6
Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing.健康志愿者静脉注射和口服给药后 S-氯胺酮和去甲氯胺酮的群体药代动力学。
Eur J Clin Pharmacol. 2015 Apr;71(4):441-7. doi: 10.1007/s00228-015-1826-y. Epub 2015 Mar 1.
7
Does the Child Behavior Checklist predict levels of preoperative anxiety at anesthetic induction and postoperative emergence delirium? A prospective cohort study.儿童行为量表能否预测麻醉诱导时的术前焦虑水平及术后苏醒期谵妄？一项前瞻性队列研究。
Minerva Anestesiol. 2015 Feb;81(2):145-56. Epub 2014 May 27.
8
[Children, parents and anxiety.].
Rev Bras Anestesiol. 2004 Oct;54(5):728-38. doi: 10.1590/s0034-70942004000500015.
9
Premedication with midazolam in young children: a comparison of four routes of administration.幼儿咪达唑仑预处理：四种给药途径的比较。
Paediatr Anaesth. 2002 Oct;12(8):685-9. doi: 10.1046/j.1460-9592.2002.00918.x.
10
The single-dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration.咪达唑仑及其主要代谢产物在儿科患者口服和静脉给药后的单剂量药代动力学。
J Clin Pharmacol. 2001 Dec;41(12):1359-69. doi: 10.1177/00912700122012832.

Is the combination of oral midazolam and ketamine as preanesthetic medication a safe and effective practice?

作者信息

Módolo Norma Sueli Pinheiro, Lima Luciana Cavalcanti, Cumino Débora de Oliveira, Nascimento Júnior Paulo do, de Barros Guilherme Antonio Moreira

机构信息

Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Especialidades Cirúrgicas e Anestesiologia, Botucatu, SP, Brazil.

Instituto Medicina Integral Professor Fernando Figueira, Recife, PE, Brazil.

出版信息

Braz J Anesthesiol. 2023 Jul-Aug;73(4):370-372. doi: 10.1016/j.bjane.2023.05.004. Epub 2023 May 26.

DOI:10.1016/j.bjane.2023.05.004
PMID:37245657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10362436/
Abstract
摘要