Yu Xuejing
Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75235, USA.
Cardiol Ther. 2023 Sep;12(3):415-443. doi: 10.1007/s40119-023-00319-4. Epub 2023 May 29.
Cardiac fibrosis is closely associated with multiple heart diseases, which are a prominent health issue in the global world. Neurohormones and cytokines play indispensable roles in cardiac fibrosis. Many signaling pathways participate in cardiac fibrosis as well. Cardiac fibrosis is due to impaired degradation of collagen and impaired fibroblast activation, and collagen accumulation results in increasing heart stiffness and inharmonious activity, leading to structure alterations and finally cardiac function decline. Herbal plants have been applied in traditional medicines for thousands of years. Because of their naturality, they have attracted much attention for use in resisting cardiac fibrosis in recent years. This review sheds light on several extracts from herbal plants, which are promising therapeutics for reversing cardiac fibrosis.
心脏纤维化与多种心脏疾病密切相关，这些疾病是全球范围内突出的健康问题。神经激素和细胞因子在心脏纤维化中发挥着不可或缺的作用。许多信号通路也参与心脏纤维化过程。心脏纤维化是由于胶原蛋白降解受损和成纤维细胞活化受损所致，胶原蛋白的积累导致心脏僵硬度增加和活动不协调，进而导致结构改变，最终使心脏功能下降。草药植物在传统医学中已应用了数千年。由于其天然性，近年来它们在抗心脏纤维化方面的应用备受关注。本综述阐述了几种草药植物提取物，它们有望成为逆转心脏纤维化的治疗药物。
