高瘦素血症与胆石病有关吗？系统评价和荟萃分析。
Is hyperleptinemia associated with gallstone disease? A systematic review and meta-analysis.
机构信息
Apeejay Stya University, Sohna, 122 103, India.
ICMR-National Institute of Research in Tribal Health, Nagpur Road, P.O. Garha, Jabalpur, 482 003, India.
出版信息
Indian J Gastroenterol. 2023 Jun;42(3):324-331. doi: 10.1007/s12664-022-01332-6. Epub 2023 May 29.
BACKGROUND
Obesity is one of the risk factors for gallstone disease (GD). Leptin hormone is known to regulate central obesity. Thus, hyperleptinemia may also be involved in gallstone disease pathogenesis. In the present study, a meta-analysis was performed to compare the leptin levels in GD and controls.
METHODS
The authors reviewed studies till April 12, 2021, which reported the serum leptin levels in gallstone patients and healthy controls. The online search involved ScienceDirect and PubMed databases. The data obtained from the research articles was scrutinized for selection criteria. Only those articles which fulfilled the inclusion criteria were subjected to meta-analysis.
RESULTS
Of 2047 articles, a total of eight studies met the inclusion and exclusion criteria and were considered for the meta-analysis. After meta-analysis, it was observed that the patients with GD had high leptin levels as compared to healthy controls. A significant level of heterogeneity was observed in the included studies (I = 89%, p < 0.01). There was no publication bias.
CONCLUSION
High leptin levels might be involved in GD pathogenesis.
背景
肥胖是胆石病（GD）的危险因素之一。瘦素激素被认为可以调节中心性肥胖。因此，高瘦素血症也可能参与胆石病的发病机制。本研究进行了荟萃分析，以比较 GD 患者和对照组的瘦素水平。
方法
作者检索了截至 2021 年 4 月 12 日的研究，这些研究报告了胆石病患者和健康对照者的血清瘦素水平。在线检索涉及 ScienceDirect 和 PubMed 数据库。对研究文章中的数据进行仔细筛选，以确定符合选择标准的文章。只有符合纳入标准的文章才进行荟萃分析。
结果
在 2047 篇文章中，共有 8 篇研究符合纳入和排除标准，并纳入荟萃分析。荟萃分析后发现，GD 患者的瘦素水平高于健康对照组。纳入的研究存在显著的异质性（I=89%，p<0.01）。不存在发表偏倚。
结论
高瘦素水平可能参与 GD 的发病机制。
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