Laboratory of Cellular and Molecular Physiology, UR UPJV 4667, University of Picardie Jules Verne Amiens, France.
Laboratory of Cellular and Molecular Physiology, UR UPJV 4667, University of Picardie Jules Verne Amiens, France; Department of Biology, Faculty of Sciences, University Ibn Zohr, Agadir 80000, Morocco.
Cell Calcium. 2023 Jul;113:102760. doi: 10.1016/j.ceca.2023.102760. Epub 2023 May 19.
Breast cancer (BC) is the second most common cancer and cause of death in women. The aggressive subtypes including triple negative types (TNBCs) show a resistance to chemotherapy, impaired immune system, and a worse prognosis. From a histological point of view, TNBCs are deficient in oestrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression. Many studies reported an alteration in the expression of calcium channels, calcium binding proteins and pumps in BC that promote proliferation, survival, resistance to chemotherapy, and metastasis. Moreover, Ca signal remodeling and calcium transporters expression have been associated to TNBCs and HER2 BC subtypes. This review provides insight into the underlying alteration of the expression of calcium-permeable channels, pumps, and calcium dependent proteins and how this alteration plays an important role in promoting metastasis, metabolic switching, inflammation, and escape to chemotherapy treatment and immune surveillance in aggressive BC including TNBCs models and highly metastatic BC tumors.
乳腺癌（BC）是女性中第二常见的癌症和死亡原因。包括三阴性类型（TNBCs）在内的侵袭性亚型对化疗具有抗性、免疫系统受损，且预后较差。从组织学的角度来看，TNBCs 缺乏雌激素受体、孕激素受体和人表皮生长因子受体 2（HER2）的表达。许多研究报告称，在 BC 中钙通道、钙结合蛋白和泵的表达发生了改变，这些改变促进了增殖、存活、对化疗的耐药性和转移。此外，Ca 信号重塑和钙转运体的表达与 TNBCs 和 HER2 BC 亚型相关。本综述深入探讨了钙通透性通道、泵和钙依赖蛋白表达的潜在改变，以及这种改变如何在促进侵袭性 BC（包括 TNBCs 模型和高转移性 BC 肿瘤）中的转移、代谢转换、炎症和逃避化疗治疗及免疫监视中发挥重要作用。
