Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
Int J Biol Macromol. 2023 Jul 15;243:125092. doi: 10.1016/j.ijbiomac.2023.125092. Epub 2023 May 27.
Scientists from across the world are being inspired by recent development in polysaccharides and their use in medical administration. Due to their extraordinary physical, chemical, and biological characteristics, polysaccharides are excellent materials for use in medicine. Acidic polysaccharides, which include Pectin, Xanthan gum, Carrageenan, Alginate, and Glycosaminoglycan, are natural polymers with carboxyl groups that are being researched for their potential as drug delivery systems. Most publications do not discuss how the different polysaccharides interact structurally in terms of drug delivery, which limits the scope of their use. The purpose of this review is to inform readers about the structural activity correlations between acidic polysaccharides, their different modification process and effects of combination of various acidic polysaccharides which have been used in drug delivery systems and expanding their potential applications, and bringing new perspectives to the fore.
来自世界各地的科学家受到多糖及其在医学应用中应用的最新进展的启发。由于其出色的物理、化学和生物特性，多糖是医学应用的绝佳材料。酸性多糖，包括果胶、黄原胶、卡拉胶、藻酸盐和糖胺聚糖，是带有羧基的天然聚合物，正在研究其作为药物传递系统的潜力。大多数出版物并未讨论不同多糖在药物传递方面的结构相互作用，这限制了它们的使用范围。本综述的目的是向读者介绍酸性多糖之间的结构活性相关性，以及它们在药物传递系统中的不同修饰过程和各种酸性多糖组合的影响，从而扩展它们的潜在应用，并为其带来新的视角。
