Bhardwaj T R, Kanwar M, Lal R, Gupta A
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Drug Dev Ind Pharm. 2000 Oct;26(10):1025-38. doi: 10.1081/ddc-100100266.
Although natural gums and their derivatives are used widely in pharmaceutical dosage forms, their use as biodegradable polymeric materials to deliver bioactive agents has been hampered by the synthetic materials. These natural polysaccharides do hold advantages over the synthetic polymers, generally because they are nontoxic, less expensive, and freely available. Natural gums can also be modified to have tailor-made materials for drug delivery systems and thus can compete with the synthetic biodegradable excipients available in the market. In this review, recent developments in the area of natural gums and their derivatives as carriers in the sustained release of drugs are explored.
尽管天然胶及其衍生物在药物剂型中被广泛使用，但它们作为可生物降解的聚合物材料来递送生物活性剂的应用却受到合成材料的阻碍。这些天然多糖相对于合成聚合物确实具有优势，通常是因为它们无毒、成本较低且易于获取。天然胶还可以被改性，以获得用于药物递送系统的定制材料，从而能够与市场上现有的合成可生物降解辅料竞争。在这篇综述中，探讨了天然胶及其衍生物作为药物缓释载体领域的最新进展。
