Institute of Chemistry, Government College University, Faisalabad, 38030, Pakistan.
Institute of Chemistry, Government College University, Faisalabad, 38030, Pakistan.
Int J Biol Macromol. 2018 Apr 1;109:1068-1087. doi: 10.1016/j.ijbiomac.2017.11.099. Epub 2017 Nov 21.
Gellan gum (GG), a linear negatively charged exopolysaccharide,is biodegradable and non-toxic in nature. It produces hard and translucent gel in the presence of metallic ions which is stable at low pH. However, GG has poor mechanical strength, poor stability in physiological conditions, high gelling temperature and small temperature window.Therefore,it is blended with different polymers such as agar, chitosan, cellulose, sodium alginate, starch, pectin, polyanaline, pullulan, polyvinyl chloride, and xanthan gum. In this article, a comprehensive overview of combination of GG with natural and synthetic polymers/compounds and their applications in biomedical field involving drug delivery system, insulin delivery, wound healing and gene therapy, is presented. It also describes the utilization of GG based materials in food and petroleum industry. All the technical scientific issues have been addressed; highlighting the recent advancement.
结冷胶（GG）是一种线性带负电荷的胞外多糖，具有生物可降解性和天然无毒的特性。在金属离子存在的情况下，它会产生坚硬透明的凝胶，在低 pH 值下稳定。然而，GG 的机械强度差、在生理条件下稳定性差、胶凝温度高且温度窗口小。因此，它与不同的聚合物如琼脂、壳聚糖、纤维素、海藻酸钠、淀粉、果胶、聚丙氨酸、普鲁兰、聚氯乙烯和黄原胶混合使用。本文综述了 GG 与天然和合成聚合物/化合物的组合及其在涉及药物输送系统、胰岛素输送、伤口愈合和基因治疗的生物医学领域中的应用。它还描述了基于 GG 的材料在食品和石油工业中的利用。所有的技术科学问题都已经得到了解决；强调了最近的进展。
