Yang Yang, Fan Dian, Zheng Bo-Hao, Zhou Sheng-Tao
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 May;54(3):497-504. doi: 10.12182/20230560304.
Metabolic reprogramming, an important hallmark of cancer, helps cancer achieve rapid proliferation. Metabolic changes in tumors regulate multiple metabolic pathways of immune cells, thereby suppressing antitumor immunity. Recent studies have been focused on in-depth investigation into the changes in the metabolism of glucose, amino acids, and lipids. Researchers have also conducted in-depth exploration of the interactive metabolic regulation of tumor cells and immune cells. Targeting various metabolic mechanisms while combining available anti-tumor therapies and enhancing the anti-tumor effects of immunotherapy by satisfying the metabolic demands of immune cells has offered new perspectives for therapies targeting the immune metabolism of tumors and enhancing anti-tumor immune responses. Studies on novel immune checkpoint molecules and cellular immunotherapies are also ongoing. Herein, we reviewed the latest findings on the mechanisms of immune metabolism underlying tumor immunosuppression and their application in immunotherapy. We also suggested some ideas for the future development of the regulation of immune metabolism.
代谢重编程是癌症的一个重要标志，有助于癌症实现快速增殖。肿瘤中的代谢变化调节免疫细胞的多种代谢途径，从而抑制抗肿瘤免疫。最近的研究集中在深入调查葡萄糖、氨基酸和脂质代谢的变化。研究人员还对肿瘤细胞和免疫细胞的交互式代谢调节进行了深入探索。在结合现有抗肿瘤疗法的同时靶向各种代谢机制，并通过满足免疫细胞的代谢需求来增强免疫疗法的抗肿瘤效果，为针对肿瘤免疫代谢和增强抗肿瘤免疫反应的治疗提供了新的视角。关于新型免疫检查点分子和细胞免疫疗法的研究也在进行中。在此，我们综述了肿瘤免疫抑制背后免疫代谢机制的最新发现及其在免疫治疗中的应用。我们还对免疫代谢调节的未来发展提出了一些想法。
