Department of Prevention and Health Care, Daping Hospital, Army Medical University, Chongqing, China.
Department of Health Management, Daping Hospital, Army Medical University, Chongqing, China.
J Alzheimers Dis. 2023;94(1):303-311. doi: 10.3233/JAD-230112.
Leisure activities and sleep duration are correlated and have been linked to cognitive function, but most studies have examined only one of these factors.
To investigate the independent and joint associations of leisure activities and sleep duration with cognitive function among older adults.
We included 7,796 participants aged≥65 years from the Chinese Longitudinal Healthy Longevity Survey during 2008-2018 (waves 5-8). Self-reported leisure activities and sleep duration were assessed at baseline, and cognitive function was measured repeatedly using the Chinese version of the Mini-Mental State Examination (MMSE) at baseline and during follow-up. We used linear mixed models to estimate regression coefficients (β) and 95% confidence intervals (CI).
The median follow-up duration was 5.77 years. After adjusting for each other and potential confounders, both lower leisure activity score (each 1-point decrease β= -0.33, 95% CI: -0.36 to -0.30) and longer sleep duration (each 1-hour increase β= -0.17, 95% CI: -0.22 to -0.11) were independently associated with lower MMSE score. Furthermore, we observed an additive interaction between leisure activities and sleep duration (pinteraction < 0.001). A combination of low leisure activity score and long sleep duration was strongly associated with decreased MMSE score (β= -2.51, 95% CI: -2.85 to -2.16) compared with the group with combined high leisure activity score and normal sleep duration.
Both leisure activities and sleep duration were independently associated with cognitive function. Moreover, the combination of leisure inactivity and prolonged sleep duration predicted worse cognitive function (a preclinical hallmark of Alzheimer's disease) in an additive manner.
休闲活动和睡眠时间是相互关联的，并且与认知功能有关，但大多数研究仅检查了其中一个因素。
调查老年人中休闲活动和睡眠时间与认知功能的独立和联合关联。
我们纳入了 2008 年至 2018 年期间（第 5 至 8 波）中国长寿纵向研究中的 7796 名年龄≥65 岁的参与者。在基线时评估了自我报告的休闲活动和睡眠时间，并且在基线和随访期间使用中文版简易精神状态检查表（MMSE）多次测量认知功能。我们使用线性混合模型来估计回归系数（β）和 95％置信区间（CI）。
中位随访时间为 5.77 年。在相互调整和潜在混杂因素后，较低的休闲活动评分（每降低 1 分β= -0.33，95％CI：-0.36 至 -0.30）和较长的睡眠时间（每增加 1 小时β= -0.17，95％CI：-0.22 至 -0.11）均与 MMSE 评分较低独立相关。此外，我们观察到休闲活动和睡眠时间之间存在附加交互作用（pinteraction < 0.001）。与组合高休闲活动评分和正常睡眠时间的组相比，低休闲活动评分和长睡眠时间的组合与 MMSE 评分降低（β= -2.51，95％CI：-2.85 至 -2.16）密切相关。
休闲活动和睡眠时间均与认知功能独立相关。此外，休闲活动不足和睡眠时间延长的组合以附加的方式预测认知功能下降（阿尔茨海默病的临床前标志）。
