School of Physical Education, Southwest Medical University, Luzhou, China.
Neurology Department, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.
Cell Tissue Res. 2023 Aug;393(2):201-215. doi: 10.1007/s00441-023-03780-8. Epub 2023 May 30.
Tendon injury is one of the most common disorders of the musculoskeletal system, with a higher likelihood of occurrence in elderly individuals and athletes. In posthealing tendons, two undesirable consequences, tissue fibrosis and a reduction in mechanical properties, usually occur, resulting in an increased probability of rerupture or reinjury; thus, it is necessary to propose an appropriate treatment. Currently, most methods do not sufficiently modulate the tendon healing process and restore the function and structure of the injured tendon to those of a normal tendon, since there is still inadequate information about the effects of multiple cellular and other relevant signaling pathways on tendon healing and how the expression of their components is regulated. microRNAs are vital targets for promoting tendon repair and can modulate the expression of biological components in signaling pathways involved in various physiological and pathological responses. miRNAs are a type of noncoding ribonucleic acid essential for regulating processes such as cell proliferation, differentiation, migration and apoptosis; inflammatory responses; vascularization; fibrosis; and tissue repair. This article focuses on the biogenesis response of miRNAs while presenting their mechanisms in tendon healing with perspectives and suggestions.
肌腱损伤是肌肉骨骼系统中最常见的疾病之一，老年人和运动员更容易发生。在愈合后的肌腱中，通常会出现两种不理想的后果，即组织纤维化和机械性能降低，这导致再次断裂或再次受伤的可能性增加；因此，有必要提出适当的治疗方法。目前，大多数方法都不能充分调节肌腱愈合过程，无法使受损肌腱的功能和结构恢复到正常肌腱的水平，因为关于多种细胞和其他相关信号通路对肌腱愈合的影响以及它们的成分表达如何受到调节的信息仍然不足。 microRNAs 是促进肌腱修复的重要靶点，它们可以调节参与各种生理和病理反应的信号通路中生物成分的表达。miRNAs 是一类非编码核糖核酸，对于调节细胞增殖、分化、迁移和凋亡、炎症反应、血管生成、纤维化和组织修复等过程至关重要。本文重点介绍了 miRNAs 的生物发生反应，并提出了它们在肌腱愈合中的作用机制及相关建议。
