Wang Bin, Chen Qiang, Zou Xiaodi, Zheng Ping, Zhu Jie
Department of Plastics, Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College, Taizhou, China.
Center for Plastic and Reconstructive Surgery, Department of Hand and Reconstructive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Front Genet. 2024 May 21;15:1396195. doi: 10.3389/fgene.2024.1396195. eCollection 2024.
Tendons serve as important weight-bearing structures that smoothly transfer forces from muscles to skeletal parts, allowing contracted muscle movements to be translated into corresponding joint movements. For body mechanics, tendon tissue plays an important role. If the tendons are damaged to varying degrees, it can lead to disability or pain in patients. That is to say, tendon injuries havea significant impact on quality of life and deserve our high attention. Compared to other musculoskeletal tissues, tendons are hypovascular and hypo-cellular, and therefore have a greater ability to heal, this will lead to a longer recovery period after injury or even disability, which will significantly affect the quality of life. There are many causes of tendon injury, including trauma, genetic factors, inflammation, aging, and long-term overuse, and the study of related mechanisms is of great significance. Currently, tendon there are different treatment modalities, like injection therapy and surgical interventions. However, they have a high failure rate due to different reasons, among which the formation of adhesions severely weakens the tissue strength, affecting the functional recovery and the patient's quality of life. A large amount of data has shown that non coding RNAs can play a huge role in this field, thus attracting widespread attention from researchers from various countries. This review summarizes the relevant research progress on non-coding RNAs in tendon injuries, providing new ideas for a deeper understanding of tendon injuries and exploring new diagnostic and therapeutic approaches.
肌腱是重要的承重结构，可将肌肉力量平稳地传递至骨骼部位，使收缩的肌肉运动转化为相应的关节运动。对于身体力学而言，肌腱组织起着重要作用。如果肌腱受到不同程度的损伤，可能导致患者残疾或疼痛。也就是说，肌腱损伤对生活质量有重大影响，值得我们高度关注。与其他肌肉骨骼组织相比，肌腱血管较少且细胞含量低，因此愈合能力更强，这会导致受伤后的恢复期更长，甚至出现残疾，严重影响生活质量。肌腱损伤的原因有很多，包括创伤、遗传因素、炎症、衰老和长期过度使用等，对相关机制的研究具有重要意义。目前，针对肌腱损伤有不同的治疗方式，如注射治疗和手术干预。然而，由于各种原因，它们的失败率很高，其中粘连的形成严重削弱了组织强度，影响功能恢复和患者生活质量。大量数据表明，非编码RNA在该领域可发挥巨大作用，从而引起各国研究人员的广泛关注。本综述总结了非编码RNA在肌腱损伤方面的相关研究进展，为更深入理解肌腱损伤及探索新的诊断和治疗方法提供新思路。
