中国南方和北方典型地区男性和女性人群中长期暴露于环境细颗粒物与肺功能的关系。
Association between long-term exposure to ambient particulate matter and pulmonary function among men and women in typical areas of South and North China.
机构信息
Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, School of Basic Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Diseases, Beijing, China.
出版信息
Front Public Health. 2023 May 12;11:1170584. doi: 10.3389/fpubh.2023.1170584. eCollection 2023.
BACKGROUND
Studies comparing the effects of different sizes and concentrations of ambient particulate matter (PM) on pulmonary function in different regions and sexes remain sparse.
OBJECTIVES
To investigate the associations of different sizes and levels of long-term ambient PM exposure with pulmonary function among people of different sexes in typical areas of South and North China.
METHODS
In 2021, a total of 1,592 participants aged 20-73 years were recruited to participate in the pulmonary function test from the baseline survey of the Diverse Life-Course Cohort (DLCC) in typical areas of Guangdong Province and Hebei Province. The three-year (2018-2020) average ambient PM concentrations were assessed from the ChinaHighPM dataset, ChinaHighPM dataset and ChinaHighPM dataset. Mean differences in pulmonary function were used in multilevel models for different regions and sexes.
RESULTS
We discovered significant associations of ambient PM exposure with reduced forced vital capacity (FVC) and increased forced expiratory volume in 1 s/forced vital capacity ratio (FEV/FVC) among men and lower levels of FEV and FVC among women, such that a 5-μg/m concentration increase in PM, PM, and PM was associated with decreases in FVC of 122.1 ml (95% confidence interval (CI): 30.8, 213.4), 54.6 ml (95% CI: 15.8, 93.3) and 42.9 ml (95% CI: 12.7, 73.1) and increases in FEV/FVC of 2.2% (95% CI: 0.6, 3.9), 1.1% (95% CI: 0.4, 1.9) and 0.9% (95% CI: 0.3, 1.5) among men and decreases in FEV of 51.1 ml (95% CI: 9.7, 92.4), 21.6 ml (95% CI: 4.3, 38.9) and 16.7 ml (95% CI: 3.3, 30.1) and in FVC of 77.8 ml (95% CI: 10.0, 145.6), 38.7 ml (95% CI: 9.0, 68.5) and 31.1 ml (95% CI: 8.1, 54.1) among women in Hebei Province. There was no association between ambient PM and pulmonary function in Guangdong Province.
CONCLUSION
Long-term exposure to different sizes and concentrations of ambient PM were associated with FEV and FVC among men and women differently. The impact of ambient PM on FVC should be of greater concerned.
背景
比较不同大小和浓度的环境颗粒物（PM）对不同地区和性别人群肺功能影响的研究仍然很少。
目的
研究不同地区和性别人群长期暴露于不同大小和水平的环境 PM 与肺功能的关系。
方法
2021 年，从广东省和河北省典型地区的多样化生命历程队列（DLCC）的基线调查中，共招募了 1592 名 20-73 岁的参与者进行肺功能测试。使用中国高 PM 数据集、中国高 PM 数据集和中国高 PM 数据集评估了 2018-2020 年的三年平均环境 PM 浓度。采用多层次模型分析不同地区和性别人群的肺功能差异。
结果
我们发现环境 PM 暴露与男性用力肺活量（FVC）降低和 1 秒用力呼气量/用力肺活量比值（FEV/FVC）增加有关，而女性的 FEV 和 FVC 水平较低，与 PM5、PM10 和 PM2.5 浓度每增加 5μg/m3，FVC 分别降低 122.1ml（95%置信区间：30.8，213.4）、54.6ml（95%置信区间：15.8，93.3）和 42.9ml（95%置信区间：12.7，73.1），FEV/FVC 分别增加 2.2%（95%置信区间：0.6，3.9）、1.1%（95%置信区间：0.4，1.9）和 0.9%（95%置信区间：0.3，1.5）。在河北省，男性 FEV 降低 51.1ml（95%置信区间：9.7，92.4）、21.6ml（95%置信区间：4.3，38.9）和 16.7ml（95%置信区间：3.3，30.1），FVC 降低 77.8ml（95%置信区间：10.0，145.6）、38.7ml（95%置信区间：9.0，68.5）和 31.1ml（95%置信区间：8.1，54.1）。而在广东省，环境 PM 与肺功能之间没有关联。
结论
长期暴露于不同大小和浓度的环境 PM 与男性和女性的 FEV 和 FVC 不同。环境 PM 对 FVC 的影响应引起更大的关注。
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