Xiong Yujie, Wang Beining, Shang Yunxia, Liu Huan, Zhan Zihao, Xu Qi, Wang Kai, Zhang Zhi, Sun Tingting
Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Front Neurosci. 2023 May 11;17:1169927. doi: 10.3389/fnins.2023.1169927. eCollection 2023.
Hoarding disorder (HD) is a chronic disease that begins early in life and does not remission unless timely treated. A large number of factors affect the presentation of HD symptoms, including a strong possessive psychology of objects and neurocognitive functioning. However, the underlying neural mechanisms of the excessive hoarding behavior in HD are still unknown. Using viral infections and brain slice electrophysiology recordings, we found that increased glutamatergic neuronal activity and decreased GABAergic neuronal activity in medial prefrontal cortex (mPFC) accelerated the hoarding-like behavior in mice. Respectively, chemogenetic manipulation to reduce glutamatergic neuronal activity or enhance GABAergic neuronal activity could improve the hoarding-like behavioral response. These results reveal a critical role played by alterations in the activity of specific types of neurons in hoarding-like behavior, and that targeted therapies for HD may be possible by precisely modulating these types of neurons.
囤积障碍（HD）是一种始于生命早期的慢性疾病，除非及时治疗否则不会缓解。大量因素影响着HD症状的表现，包括对物品强烈的占有心理和神经认知功能。然而，HD中过度囤积行为的潜在神经机制仍不清楚。通过病毒感染和脑片电生理记录，我们发现内侧前额叶皮质（mPFC）中谷氨酸能神经元活动增加和γ-氨基丁酸能神经元活动减少会加速小鼠的囤积样行为。分别地，通过化学遗传学操作降低谷氨酸能神经元活动或增强γ-氨基丁酸能神经元活动可以改善囤积样行为反应。这些结果揭示了特定类型神经元活动的改变在囤积样行为中所起的关键作用，并且通过精确调节这些类型的神经元可能实现针对HD的靶向治疗。
