Tajik Fatemeh, Alian Fatemeh, Yousefi Mohammad, Azadfallah Ali, Hoseini Aref, Mohammadi Forogh, Karimi-Dehkordi Maryam, Alizadeh-Fanalou Shahin
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Heliyon. 2023 May 9;9(5):e15991. doi: 10.1016/j.heliyon.2023.e15991. eCollection 2023 May.
MicroRNAs (miRNAs or miRs) are non-coding, single-stranded, endogenous RNAs that regulate various biological processes, most notably the pathophysiology of many human malignancies. It process is accomplished by binding to 3'-UTR mRNAs and controlling gene expression at the post-transcriptional level. As an oncogene, miRNAs can either accelerate cancer progression or slow it down as a tumor suppressor. MicroRNA-372 (miR-372) has been found to have an abnormal expression in numerous human malignancies, implying that the miRNA plays a role in carcinogenesis. It is both increased and downregulated in various cancers, and it serves as both a tumor suppressor and an oncogene. This study examines the functions of miR-372 as well as the LncRNA/CircRNA-miRNA-mRNA signaling pathways in various malignancies and analyses its potential prognostic, diagnostic, and therapeutic implications.
微小RNA（miRNA或miR）是一类非编码的单链内源性RNA，可调节多种生物学过程，尤其是许多人类恶性肿瘤的病理生理学过程。该过程通过与3'-UTR mRNA结合并在转录后水平控制基因表达来完成。作为一种癌基因，miRNA既可以加速癌症进展，也可以作为肿瘤抑制因子减缓癌症进展。已发现微小RNA-372（miR-372）在多种人类恶性肿瘤中存在异常表达，这表明该miRNA在致癌过程中发挥作用。它在各种癌症中既有上调也有下调，既作为肿瘤抑制因子又作为癌基因。本研究探讨了miR-372在各种恶性肿瘤中的功能以及长链非编码RNA/环状RNA-miRNA-信使核糖核酸信号通路，并分析了其潜在的预后、诊断和治疗意义。
