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一种考虑停用苯二氮䓬类抗焦虑药的焦虑症决策辅助工具的开发与可接受性

Development and acceptability of a decision aid for anxiety disorder considering discontinuation of benzodiazepine anxiolytic.

作者信息

Aoki Yumi, Takaesu Yoshikazu, Inada Ken, Yamada Hiroki, Murao Tomohiko, Kikuchi Toshiaki, Takeshima Masahiro, Tani Masayuki, Mishima Kazuo, Otsubo Tempei

机构信息

Department of Psychiatric and Mental Health Nursing, Graduate School of Nursing, St. Luke's International University, Tokyo, Japan.

Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan.

出版信息

Front Psychiatry. 2023 May 12;14:1083568. doi: 10.3389/fpsyt.2023.1083568. eCollection 2023.

Abstract

AIM

We aimed to develop a decision aid (DA) for individuals with anxiety disorders who consider tapering benzodiazepine (BZD) anxiolytics, and if tapering, tapering BZD anxiolytics with or without cognitive behavioral therapy (CBT) for anxiety. We also assessed its acceptability among stakeholders.

METHODS

First, we conducted a literature review regarding anxiety disorders to determine treatment options. We cited the results of the systematic review and meta-analysis, which we conducted previously, to describe the related outcomes of two options: tapering BZD anxiolytics with CBT and tapering BZD anxiolytics without CBT. Second, we developed a DA prototype in accordance with the International Patient Decision Aid Standards. We carried out a mixed methods survey to assess the acceptability among stakeholders including those with anxiety disorders and healthcare providers.

RESULTS

Our DA provided information such as explanation of anxiety disorders, options of tapering or not tapering BZD anxiolytics (if tapering, the options of tapering BZD anxiolytics with or without CBT) for anxiety disorder, benefits and risks of each option, and a worksheet for value clarification. For patients ( = 21), the DA appeared to be acceptable language (86%), adequate information (81%), and well-balanced presentation (86%). The developed DA was also acceptable for healthcare providers ( = 10).

CONCLUSION

We successfully created a DA for individuals with anxiety disorders who consider tapering BZD anxiolytics, which was acceptable for both patients and healthcare providers. Our DA was designed to assist patients and healthcare providers to involve decision-making about whether to taper BZD anxiolytics or not.

摘要

目的

我们旨在为考虑逐渐减少苯二氮䓬类(BZD)抗焦虑药用量的焦虑症患者开发一种决策辅助工具(DA),若要逐渐减少用量,则在逐渐减少BZD抗焦虑药用量的同时联合或不联合用于治疗焦虑症的认知行为疗法(CBT)。我们还评估了其在利益相关者中的可接受性。

方法

首先,我们针对焦虑症进行了一项文献综述以确定治疗方案。我们引用了之前进行的系统评价和荟萃分析的结果,以描述两种方案的相关结局:联合CBT逐渐减少BZD抗焦虑药用量和不联合CBT逐渐减少BZD抗焦虑药用量。其次,我们根据国际患者决策辅助工具标准开发了一个DA原型。我们开展了一项混合方法调查,以评估包括焦虑症患者和医疗服务提供者在内的利益相关者的可接受性。

结果

我们的DA提供了诸如焦虑症的解释、针对焦虑症逐渐减少或不逐渐减少BZD抗焦虑药用量的选择(若逐渐减少用量,则包括联合或不联合CBT逐渐减少BZD抗焦虑药用量的选择)、每种选择的益处和风险,以及一份用于价值澄清的工作表等信息。对于患者(n = 21)而言,DA在语言方面似乎是可接受的(86%)、信息充足(81%)且呈现方式平衡良好(86%)。所开发的DA对医疗服务提供者(n = 10)而言也是可接受的。

结论

我们成功为考虑逐渐减少BZD抗焦虑药用量的焦虑症患者创建了一种DA,患者和医疗服务提供者均可接受。我们的DA旨在帮助患者和医疗服务提供者参与关于是否逐渐减少BZD抗焦虑药用量的决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3f1/10213963/3182f197bfac/fpsyt-14-1083568-g001.jpg

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