Ye Hua, Yang Jia-Ming, Luo Yun, Long Yi, Zhang Jia-Hong, Zhong Yan-Biao, Gao Feng, Wang Mao-Yuan
Gannan Medical University, Ganzhou City, Jiangxi, China.
Department of Rehabilitation Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou City, Jiangxi, China.
Front Nutr. 2023 May 11;10:1093988. doi: 10.3389/fnut.2023.1093988. eCollection 2023.
We performed a systematic review and meta-analysis of existing randomized controlled trials (RCTs) to assess whether dietary supplements can prevent loss of muscle mass and strength during muscle disuse.
We searched the following databases: PubMed, Embase, Cochrane, Scopus, Web of Science, and CINAHL for RCTs assessing the effect of dietary supplements on disuse muscular atrophy without language and time restrictions. Muscle strength and leg lean mass were used as the primary outcome indicators. Muscle cross-sectional area (CSA), muscle fiber type distribution, peak aerobic capacity and muscle volume were used as secondary outcome indicators. The risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool. Heterogeneity was tested using the statistic index. Mean and standard deviation of outcome indicators were extracted from the intervention and control groups to calculate effect sizes and 95% confidence intervals, with the significance level set at < 0.05.
Twenty RCTs were included with a total of 339 subjects. The results showed that dietary supplements had no effect on muscle strength, CSA, muscle fiber type distribution, peak aerobic capacity or muscle volume. But dietary supplements have a protective effect on the lean mass of the legs.
Dietary supplements can improve lean leg mass, but did not show a tendency to have an effect on muscle strength, CSA, muscle fiber type distribution, peak aerobic capacity or muscle volume during muscle disuse.
https://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier: CRD42022370230.
我们对现有的随机对照试验（RCT）进行了系统评价和荟萃分析，以评估膳食补充剂是否能预防肌肉废用期间肌肉质量和力量的损失。
我们检索了以下数据库：PubMed、Embase、Cochrane、Scopus、Web of Science和CINAHL，以查找评估膳食补充剂对废用性肌肉萎缩影响的RCT，无语言和时间限制。肌肉力量和腿部瘦体重用作主要结局指标。肌肉横截面积（CSA）、肌纤维类型分布、峰值有氧运动能力和肌肉体积用作次要结局指标。使用Cochrane协作网的偏倚风险工具评估偏倚风险。使用统计指标检验异质性。从干预组和对照组中提取结局指标的均值和标准差，以计算效应量和95%置信区间，显著性水平设定为<0.05。
纳入20项RCT，共339名受试者。结果表明，膳食补充剂对肌肉力量、CSA、肌纤维类型分布、峰值有氧运动能力或肌肉体积没有影响。但膳食补充剂对腿部瘦体重有保护作用。
膳食补充剂可改善腿部瘦体重，但在肌肉废用期间对肌肉力量、CSA、肌纤维类型分布、峰值有氧运动能力或肌肉体积未显示出有影响的趋势。
https://www.crd.york.ac.uk/PROSPERO/#recordDetails，标识符：CRD42022370230。
