Du Yang, Wang Weidong, Zhang Lili, Li Yuan, Chen Xiang, Yang Hui, Ding Xin
Department of Neurology, Chengdu Second People's Hospital, Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China.
Front Immunol. 2024 Dec 17;15:1474354. doi: 10.3389/fimmu.2024.1474354. eCollection 2024.
Anti-GQ1b antibody syndrome is a spectrum of autoimmune disorders affecting nervous systems. We report a case of a 53-year-old woman presenting mydriasis with acute onset of periorbital pain, photophobia, and subsequently, diplopia. Despite weakly positive anti-GQ1b IgG antibody, the patient exhibited atypical features with isolated ophthalmoplegia and absence of classic Miller-Fisher syndrome triad. Symptoms improved spontaneously without specific immunotherapy. This case highlights the variable clinical presentations of anti-GQ1b antibody syndrome, emphasizing the importance of considering this diagnosis in patients with unexplained iris abnormalities and ophthalmoplegia.
抗GQ1b抗体综合征是一系列影响神经系统的自身免疫性疾病。我们报告一例53岁女性病例，该患者出现瞳孔散大，并伴有眶周疼痛急性发作、畏光，随后出现复视。尽管抗GQ1b IgG抗体弱阳性，但该患者表现出非典型特征，仅有孤立性眼肌麻痹，且无典型的米勒-费希尔综合征三联征。症状未经特异性免疫治疗而自发改善。该病例突出了抗GQ1b抗体综合征临床表现的多样性，强调了在不明原因虹膜异常和眼肌麻痹患者中考虑这一诊断的重要性。
