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Acute flaccid paralysis due to West nile virus infection in adults: A paradigm shift entity.成人西尼罗河病毒感染所致急性弛缓性麻痹:一种范式转变的疾病实体。
Ann Indian Acad Neurol. 2014 Jan;17(1):85-8. doi: 10.4103/0972-2327.128561.
2
West nile virus in the United States - a historical perspective.美国西尼罗河病毒——历史透视。
Viruses. 2013 Dec 10;5(12):3088-108. doi: 10.3390/v5123088.
3
Unusual case of West Nile Virus flaccid paralysis in a 10-year-old child.儿童西尼罗河病毒弛缓性麻痹 10 例报告
Pediatr Neurol. 2013 May;48(5):393-6. doi: 10.1016/j.pediatrneurol.2012.12.017.
4
Estimated cumulative incidence of West Nile virus infection in US adults, 1999-2010.1999-2010 年美国成年人西尼罗河病毒感染的估计累积发病率。
Epidemiol Infect. 2013 Mar;141(3):591-5. doi: 10.1017/S0950268812001070. Epub 2012 May 28.
5
Plasma cell cerebrospinal fluid pleocytosis does not predict West Nile virus infection.浆细胞性脑脊液细胞增多症不能预测西尼罗河病毒感染。
J Biomed Biotechnol. 2012;2012:697418. doi: 10.1155/2012/697418. Epub 2011 Nov 2.
6
Prognosis of West Nile virus associated acute flaccid paralysis: a case series.西尼罗河病毒相关急性弛缓性麻痹的预后:病例系列
J Med Case Rep. 2011 Aug 19;5:395. doi: 10.1186/1752-1947-5-395.
7
CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis.250例血清学确诊的西尼罗河病毒脑膜炎和脑炎患者的脑脊液检查结果
Neurology. 2006 Feb 14;66(3):361-5. doi: 10.1212/01.wnl.0000195890.70898.1f. Epub 2005 Dec 28.
8
Recovery and prognosticators of paralysis in West Nile virus infection.西尼罗河病毒感染所致麻痹的恢复情况及预后因素
J Neurol Sci. 2005 Sep 15;236(1-2):73-80. doi: 10.1016/j.jns.2005.05.007.
9
West Nile Virus: a case report with flaccid paralysis and cervical spinal cord: MR imaging findings.西尼罗河病毒:一例伴有弛缓性麻痹和颈脊髓病变的病例报告:磁共振成像表现
AJNR Am J Neuroradiol. 2005 Jan;26(1):26-9.
10
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis.Toll样受体3介导西尼罗河病毒进入大脑,引发致死性脑炎。
Nat Med. 2004 Dec;10(12):1366-73. doi: 10.1038/nm1140. Epub 2004 Nov 21.

西尼罗河病毒相关急性弛缓性麻痹

West Nile virus-associated acute flaccid paralysis.

作者信息

Alker Ashely

机构信息

Department of Medicine, George Washington University, Washington, DC, USA.

出版信息

BMJ Case Rep. 2015 May 2;2015:bcr2014206480. doi: 10.1136/bcr-2014-206480.

DOI:10.1136/bcr-2014-206480
PMID:25935909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4434305/
Abstract

A 43-year-old woman presented to George Washington emergency department with 48 h of new-onset inguinal pain. Physical examination revealed a diffuse maculopapular rash involving the palms and soles, as well as inguinal lymphadenopathy. The patient denied recent travel outside of Washington, DC, and had no known sick contacts. She was admitted to the hospital for observation. Within 24 h of admission she developed left lower extremity flaccid paralysis, with loss of left patellar and Achilles reflexes. cerebrospinal fluid was positive for West Nile virus IgG and IgM antibodies, so methylprednisone 125 mg intravenously two times per day was started. On day 7, the patient recovered reflexes and continued to regain strength in the left lower extremity. She was discharged on day 9 on prednisone taper, with outpatient follow-up.

摘要

一名43岁女性因腹股沟疼痛新发48小时就诊于乔治·华盛顿大学急诊室。体格检查发现手掌和足底出现弥漫性斑丘疹,以及腹股沟淋巴结病。患者否认近期出过华盛顿特区,也没有已知的患病接触史。她被收入院观察。入院后24小时内,她出现左下肢弛缓性麻痹,左侧髌反射和跟腱反射消失。脑脊液检测西尼罗河病毒IgG和IgM抗体呈阳性,因此开始静脉注射甲泼尼龙125毫克,每日两次。第7天,患者恢复了反射,左下肢力量也持续恢复。她在第9天出院,逐渐减量服用泼尼松,并进行门诊随访。