Hess L W, O'Brien W F, Holmberg J A, Winkel C A, Monaghan W P, Hemming V G
Obstet Gynecol. 1986 Jul;68(1):25-8.
To ascertain the influence of pregnancy on plasma concentrations of fibronectin, we quantified plasma concentrations of fibronectin in 22 normal, pregnant women during the first, second, and third trimesters; at the time of delivery; and at six weeks and eight months postpartum, using a rapid, immunoturbidimetric procedure. Mean plasma concentrations of fibronectin rose significantly throughout pregnancy, and were significantly greater than umbilical cord plasma concentrations. Maternal plasma concentrations of fibronectin at six weeks postpartum were similar to those observed at the time of delivery, but returned to concentrations observed in nonpregnant women by eight months postpartum. No significant differences between concentrations of fibronectin in amniotic fluid obtained during the second and third trimesters of pregnancy were observed. Six-week postpartum values appeared to depend upon the type of infant feeding as values rose in bottle feeding but fell in breast-feeding mothers.
为确定妊娠对血浆纤连蛋白浓度的影响，我们采用快速免疫比浊法，对22名正常孕妇在妊娠早期、中期和晚期、分娩时、产后六周和八个月时的血浆纤连蛋白浓度进行了定量。整个孕期血浆纤连蛋白的平均浓度显著升高，且显著高于脐带血血浆浓度。产后六周时母体血浆纤连蛋白浓度与分娩时观察到的浓度相似，但到产后八个月时恢复到非孕妇观察到的浓度。妊娠中期和晚期获得的羊水纤连蛋白浓度之间未观察到显著差异。产后六周的值似乎取决于婴儿喂养方式，人工喂养的母亲该值升高，而母乳喂养的母亲该值下降。
