Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Institute of Legal Medicine, University Hospital, Goethe University, Frankfurt/Main, Germany.
Clin Pharmacol Ther. 2023 Aug;114(2):423-433. doi: 10.1002/cpt.2958. Epub 2023 Jun 11.
2,5-dimethoxy-4-bromophenethylamine (2C-B) is a hallucinogenic phenethylamine derived from mescaline. Observational and preclinical data have suggested it to be capable of producing both subjective and emotional effects on par with other classical psychedelics and entactogens. Whereas it is the most prevalently used novel serotonergic hallucinogen to date, it's acute effects and distinctions from classical progenitors have yet to be characterized in a controlled study. We assessed for the first time the immediate acute subjective, cognitive, and cardiovascular effects of 2C-B (20 mg) in comparison to psilocybin (15 mg) and placebo in a within-subjects, double-blind, placebo-controlled study of 22 healthy psychedelic-experienced participants. 2C-B elicited alterations of waking consciousness of a psychedelic nature, with dysphoria, subjective impairment, auditory alterations, and affective elements of ego dissolution largest under psilocybin. Participants demonstrated equivalent psychomotor slowing and spatial memory impairments under either compound compared with placebo, as indexed by the Digit Symbol Substitution Test, Tower of London, and Spatial Memory Task. Neither compound produced empathogenic effects on the Multifaceted Empathy Test. 2C-B induced transient pressor effects to a similar degree as psilocybin. The duration of self-reported effects of 2C-B was shorter than that of psilocybin, largely resolving within 6 hours. Present findings support the categorization of 2C-B as a psychedelic of moderate experiential depth at doses given. Tailored dose-effect studies are needed to discern the pharmacokinetic dependency of 2C-B's experiential overlaps.
2,5-二甲氧基-4-溴苯乙胺（2C-B）是一种致幻苯乙胺，源自三甲氧苯乙胺。观察性和临床前数据表明，它能够产生与其他经典迷幻剂和快感增强剂相当的主观和情绪效果。虽然它是迄今为止最流行的新型血清素致幻剂，但它的急性效应及其与经典前体的区别尚未在对照研究中得到描述。我们首次评估了 20 毫克 2C-B 与 15 毫克裸头草碱和安慰剂在 22 名有经验的健康致幻剂参与者的双盲、安慰剂对照的内类研究中的即时急性主观、认知和心血管效应。2C-B 引起了清醒意识的改变，具有迷幻性质，伴有抑郁、主观障碍、听觉改变和自我解体的情感元素，在裸头草碱下最大。与安慰剂相比，参与者在任何一种化合物下都表现出同等的运动速度减慢和空间记忆障碍，这由数字符号替代测试、伦敦塔和空间记忆任务来衡量。两种化合物都没有在多方面同理心测试中产生同理心效应。2C-B 引起的升压作用与裸头草碱相似。2C-B 自我报告的效应持续时间短于裸头草碱，主要在 6 小时内消除。目前的发现支持将 2C-B 归类为在给予的剂量下具有中等体验深度的致幻剂。需要进行定制的剂量-效应研究，以辨别 2C-B 体验重叠的药代动力学依赖性。
