Sun Junyan, Ma Jinghong, Gao Linlin, Wang Junling, Zhang Dongling, Chen Lili, Fang Jiliang, Feng Tao, Wu Tao
Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
NPJ Parkinsons Dis. 2023 May 30;9(1):81. doi: 10.1038/s41531-023-00532-x.
Locus coeruleus (LC) is severely affected in Parkinson's Disease (PD). However, alterations in LC-related resting-state networks (RSNs) in PD remain unclear. We used resting-state functional MRI to investigate the alterations in functional connectivity (FC) of LC-related RSNs and the associations between RSNs changes and clinical features in idiopathic rapid eye movement sleep behavior disorder (iRBD) and PD patients with (PD) and without RBD (PD). There was a similarly disrupted FC pattern of LC-related RSNs in iRBD and PD patients, whereas LC-related RSNs were less damaged in PD patients than that in patients with iRBD and PD. The FC of LC-related RSNs correlated with cognition and duration in iRBD, depression in PD, and cognition and severity of RBD in patients with PD. Our findings demonstrate that LC-related RSNs are significantly disrupted in the prodromal stage of α-synucleinopathies and proposed body-first PD (PD), but are less affected in brain-first PD (PD).
蓝斑（LC）在帕金森病（PD）中受到严重影响。然而，PD中与LC相关的静息态网络（RSN）的改变仍不清楚。我们使用静息态功能磁共振成像来研究特发性快速眼动睡眠行为障碍（iRBD）以及伴或不伴RBD的PD患者中与LC相关的RSN的功能连接（FC）改变，以及RSN变化与临床特征之间的关联。iRBD和PD患者中与LC相关的RSN存在类似的FC模式破坏，而与LC相关的RSN在PD患者中的受损程度低于iRBD和PD患者。与LC相关的RSN的FC与iRBD中的认知和病程、PD中的抑郁以及PD患者中的认知和RBD严重程度相关。我们的研究结果表明，与LC相关的RSN在α-突触核蛋白病的前驱期和提出的身体优先型PD（PD）中显著破坏，但在脑优先型PD（PD）中受影响较小。
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