Key Laboratory of Post-Neurotrauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Department of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China.
BMC Med. 2023 May 30;21(1):199. doi: 10.1186/s12916-023-02895-7.
Contact sports athletes and military personnel who suffered a repetitive mild traumatic brain injury (rmTBI) are at high risk of neurodegenerative diseases such as advanced dementia and chronic traumatic encephalopathy (CTE). However, due to the lack of specific biological indicators in clinical practice, the diagnosis and treatment of rmTBI are quite limited.
We used 2-methacryloyloxyethyl phosphorylcholine (MPC)-nanocapsules to deliver immunoglobulins (IgG), which can increase the delivery efficiency and specific target of IgG while reducing the effective therapeutic dose of the drug.
Our results demonstrated that MPC-capsuled immunoglobulins (MPC-n (IgG)) significantly alleviated cognitive impairment, hippocampal atrophy, p-Tau deposition, and myelin injury in rmTBI mice compared with free IgG. Furthermore, MPC-n (IgG) can also effectively inhibit the activation of microglia and the release of inflammatory factors.
In the present study, we put forward an efficient strategy for the treatment of rmTBI-related cognitive impairment and provide evidence for the administration of low-dose IgG.
反复轻度创伤性脑损伤（rmTBI）的接触性运动运动员和军人患神经退行性疾病（如晚期痴呆和慢性创伤性脑病（CTE））的风险很高。然而，由于临床实践中缺乏特定的生物指标，rmTBI 的诊断和治疗受到很大限制。
我们使用 2-（甲基丙烯酰氧）乙基磷酸胆碱（MPC）-纳米胶囊来输送免疫球蛋白（IgG），这可以提高 IgG 的输送效率和特异性靶向，同时降低药物的有效治疗剂量。
与游离 IgG 相比，MPC-包封的免疫球蛋白（MPC-n（IgG））显著减轻了 rmTBI 小鼠的认知障碍、海马萎缩、p-Tau 沉积和髓鞘损伤。此外，MPC-n（IgG）还可以有效抑制小胶质细胞的激活和炎症因子的释放。
在本研究中，我们提出了一种治疗与 rmTBI 相关认知障碍的有效策略，并为低剂量 IgG 的给药提供了证据。
