Keck School of Medicine of the University of Southern California, Los Angeles, California.
Caruso Department of Otolaryngology-Head & Neck Surgery, Keck, School of Medicine of the University of Southern California, Los Angeles, California.
Otol Neurotol. 2023 Jul 1;44(6):611-618. doi: 10.1097/MAO.0000000000003895. Epub 2023 May 31.
Assess the association between cannabis use and tinnitus in a nationally representative sample of US adults.
Cross-sectional.
Population-based.
Adults aged 20 to 59 years who participated in 2011 to 2012 and 2015 to 2016 National Health and Nutrition Examination Survey (NHANES) with available data on tinnitus, audiometry, and substance use.
None.
Tinnitus, demographic information, and medical history were obtained from NHANES questionnaires. Tinnitus was defined as bothersome tinnitus in the past year. Cannabis use was categorized as never use, low-volume use (1-2 pipes/joints per day), and high-volume use (3+ pipes/joints per day). Multivariable regression models with interaction and mediation analyses were conducted. Sampling weights were incorporated to yield results generalizable to the US population.
Tinnitus prevalence was significantly higher among high-volume cannabis users (odds ratio [OR], 20.5%; 95% confidence interval [CI], 16.0-26.0%]) and low-volume users (OR, 17.0%; 95% CI, 14.3-20.0%) than nonusers (OR, 12.0%; 95% CI, 10.4-13.9%). High-volume cannabis use was significantly associated with tinnitus relative to nonusers in multivariable models adjusting for demographics, cardiovascular factors, hearing loss, noise exposure, and depression (OR, 2.05; 95% CI, 1.1-3.9). Tinnitus severity was comparable among high volume, low volume, and noncannabis users. There was no significant mediation or interaction of depression affecting the association between cannabis use and tinnitus.
Bothersome tinnitus prevalence was significantly higher among cannabis users relative to nonusers. High-volume cannabis use was independently associated with tinnitus in a multivariable model accounting for relevant factors including depression. Future study is warranted to elucidate the impact of various levels of cannabis use on tinnitus.
在全美代表性的成年人群体中评估大麻使用与耳鸣之间的关联。
横断面研究。
基于人群。
年龄在 20 至 59 岁之间的成年人，他们参加了 2011 年至 2012 年和 2015 年至 2016 年的国家健康和营养调查（NHANES），并提供了耳鸣、听力测试和物质使用的可用数据。
无。
耳鸣、人口统计学信息和病史均来自 NHANES 调查问卷。耳鸣定义为过去一年令人困扰的耳鸣。大麻使用分为从未使用、低量使用（每天 1-2 管/接头）和高量使用（每天 3+管/接头）。进行了多变量回归模型分析，并进行了交互和中介分析。纳入了抽样权重，以得出可推广至美国人群的结果。
与非使用者相比，高量大麻使用者（比值比 [OR]，20.5%；95%置信区间 [CI]，16.0-26.0%）和低量使用者（OR，17.0%；95% CI，14.3-20.0%）的耳鸣患病率显著更高。在调整人口统计学、心血管因素、听力损失、噪声暴露和抑郁因素的多变量模型中，高量大麻使用与非使用者相比与耳鸣显著相关（OR，2.05；95% CI，1.1-3.9）。高量、低量和非大麻使用者的耳鸣严重程度相当。抑郁对大麻使用与耳鸣之间关联的中介或交互作用无统计学意义。
与非使用者相比，令人困扰的耳鸣患病率在大麻使用者中显著更高。在考虑包括抑郁在内的各种相关因素的多变量模型中，高量大麻使用与耳鸣独立相关。未来的研究需要阐明各种水平的大麻使用对耳鸣的影响。
