Cooke R R, Pratt R
Pathology. 1986 Jan;18(1):94-7. doi: 10.3109/00313028609090834.
A prospective study of 100 acutely ill patients was carried out to assess the value of the free thyroxine (FT4) assay as a replacement screening procedure for the free thyroxine index (FTI). We found that the FT4 assay was significantly influenced by the albumin concentration, so that the number of follow-up tests required increased markedly. This was especially true at the low end of the FT4 range where the need for thyrotropin assays increased by 162%. The free triiodothyronine (FT3) assay was also shown to be albumin dependent. It is not useful to replace one set of difficulties due to protein binding with another, and overall it was concluded that it is not cost-effective to screen hospital patients for thyroid dysfunction using free hormone assays based on labelled analogue techniques.
对100例急性病患者进行了一项前瞻性研究，以评估游离甲状腺素（FT4）检测作为游离甲状腺素指数（FTI）替代筛查程序的价值。我们发现，FT4检测受到白蛋白浓度的显著影响，因此所需的后续检测数量显著增加。在FT4范围的低端尤其如此，在该范围内促甲状腺激素检测的需求增加了162%。游离三碘甲状腺原氨酸（FT3）检测也显示出依赖白蛋白。用另一组因蛋白质结合产生的困难来替代一组困难并无益处，总体而言，得出的结论是，使用基于标记类似物技术的游离激素检测来筛查医院患者的甲状腺功能障碍不具有成本效益。
