Erasmus MC, Department of Internal Medicine, Academic Center for Thyroid Diseases, Wytemaweg 80, 3015 CN, Rotterdam, the Netherlands.
Erasmus MC, Department of Internal Medicine, Academic Center for Thyroid Diseases, Wytemaweg 80, 3015 CN, Rotterdam, the Netherlands.
Best Pract Res Clin Endocrinol Metab. 2020 Jul;34(4):101431. doi: 10.1016/j.beem.2020.101431. Epub 2020 Jun 18.
Thyroid hormones are crucial for normal pregnancy and fetal development. Large physiological changes occur during pregnancy, posing challenges for the correct interpretation of thyroid function tests. TSH concentrations are the principal first test to rule out thyroid disease taking into account trimester-specific reference ranges. Free T4 (FT4) measurements by immuno-assays may be subject to interference by endogenous and exogenous factors. The relevance of measuring free T3 (FT3) during pregnancy is unclear. Thyroid autoimmunity is well-reflected by the presence of antibodies against TPO. TPO-antibody positivity is associated with an increased risk of adverse pregnancy outcomes.
甲状腺激素对正常妊娠和胎儿发育至关重要。妊娠期间会发生较大的生理变化，这给甲状腺功能检测的正确解读带来了挑战。考虑到各孕期特异的参考范围，TSH 浓度是首要的排除甲状腺疾病的检测指标。免疫分析法测定的游离 T4（FT4）可能会受到内源性和外源性因素的干扰。妊娠期测定游离 T3（FT3）的意义尚不清楚。甲状腺过氧化物酶抗体（TPOAb）的存在很好地反映了甲状腺自身免疫。TPOAb 阳性与不良妊娠结局风险增加相关。
