Srivastava Neha, Singh Kalpana, Singh Nisha, Mahdi Abbas Ali
Department of Biochemistry, King George's Medical University, 226003 Lucknow, Uttar Pradesh India.
Department of Obstetrics & Gynaecology, King George's Medical University, 226003 Lucknow, Uttar Pradesh India.
J Diabetes Metab Disord. 2023 Feb 13;22(1):639-648. doi: 10.1007/s40200-023-01188-3. eCollection 2023 Jun.
Gestational diabetes mellitus (GDM) is a state of leptin resistance which develops a vicious cycle of hyperinsulinemia and hyperleptinemia leading to aggravation of an inflammatory situation. This study was done to find out the association between IL-6, leptin and insulin in gestational diabetes among North Indian women.
This cross-sectional study included 100 GDM, 100 non-GDM and 50 non-pregnant women. (Diabetes in Pregnancy Study Group India) criteria was used for screening GDM among pregnant women. GDM and non-GDM pregnant women were further categorized into three groups according to the trimester of pregnancy. Serum IL-6, leptin and insulin were measured in all the enrolled women.
Serum IL-6 levels were significantly higher among GDM women as compared to non-GDM and non-pregnant women. Although the mean serum leptin and insulin levels were higher in GDM, but the difference was not statistically significant. When GDM and non-GDM women were categorized into three trimester, serum leptin levels were found to be significantly higher in 3rd trimester (p < 0.002) and IL-6 in 1st trimester (p < 0.017) among GDM women. No correlation was found between serum IL-6, leptin and insulin in GDM.
Absence of any significant association between leptin and IL-6 signifies that leptin may not be associated with inflammation in gestational diabetes. However, IL-6 may serve as an early marker for screening glucose intolerance during pregnancy.
The online version contains supplementary material available at 10.1007/s40200-023-01188-3.
妊娠期糖尿病（GDM）是一种瘦素抵抗状态，会形成高胰岛素血症和高瘦素血症的恶性循环，导致炎症情况加重。本研究旨在探讨印度北部女性妊娠期糖尿病患者中白细胞介素-6（IL-6）、瘦素和胰岛素之间的关联。
这项横断面研究纳入了100例妊娠期糖尿病患者、100例非妊娠期糖尿病患者和50例未怀孕女性。采用（印度妊娠糖尿病研究组）标准对孕妇进行妊娠期糖尿病筛查。妊娠期糖尿病和非妊娠期糖尿病孕妇根据妊娠 trimester 进一步分为三组。对所有纳入的女性测量血清IL-6、瘦素和胰岛素水平。
与非妊娠期糖尿病和未怀孕女性相比，妊娠期糖尿病女性的血清IL-6水平显著更高。虽然妊娠期糖尿病患者的血清瘦素和胰岛素平均水平较高，但差异无统计学意义。当将妊娠期糖尿病和非妊娠期糖尿病女性分为三个 trimester 时，发现妊娠期糖尿病女性在孕晚期血清瘦素水平显著更高（p < 0.002），在孕早期IL-6水平显著更高（p < 0.017）。妊娠期糖尿病患者血清IL-6、瘦素和胰岛素之间未发现相关性。
瘦素与IL-6之间无任何显著关联表明，瘦素可能与妊娠期糖尿病的炎症无关。然而，IL-6可能作为孕期筛查葡萄糖不耐受的早期标志物。
在线版本包含可在10.1007/s40200-023-01188-3获取的补充材料。
