在中国人群基于研究中，阴道局部细胞因子 IL-2 与高危型人乳头瘤病毒感染与宫颈上皮内瘤变的相互作用。

Interactions between vaginal local cytokine IL-2 and high-risk human papillomavirus infection with cervical intraepithelial neoplasia in a Chinese population-based study.

机构信息

Departments of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Hong Kong SAR, China.

出版信息

Front Cell Infect Microbiol. 2023 May 15;13:1109741. doi: 10.3389/fcimb.2023.1109741. eCollection 2023.

DOI:10.3389/fcimb.2023.1109741

PMID:37256111

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10225571/

Abstract

BACKGROUND

Although interleukin-2 (IL-2) has long been associated with cancer development, its roles in the development of cervical cancer remains unclear. Few studies examined the associations between IL-2 and high-risk human papillomavirus (HPV) with risk of cervical intraepithelial neoplasia (CIN).

OBJECTIVE

We aimed to assess the association of IL-2 and high-risk HPV infection with risk of CIN as well as their interactions on the risk of CIN.

DESIGN

We performed a cross-sectional analysis of screening data in 2285 women aged 19-65 years who participated in an ongoing community-based cohort of 40,000 women in Shanxi, China in 2014-2015. Both categorical and spline analyses were used to evaluation the association between IL-2 in the local vaginal fluids and prevalence of CIN. In addition, 1503 controls were followed up until January 31, 2019), the nested case-control study design was adopted to evaluate the association of vaginal lavage IL-2 levels and the risk of CIN progression.

RESULTS

After adjusting for potential confounders, IL-2 levels were statistically inversely associated with prevalence of CIN (the 1st versus 4th quartile IL-2 levels: the respective odds ratio [OR] and 95% confidence intervals [CI] was: = 1.75 [1.37, 2.23] for CIN, 1.32 [1.01, 1.73] for CIN I, and 3.53 [2.26, 5.52] for CIN II/III). Increased IL-2 levels were inversely associated with prevalence of CIN (P-overall<0.01, P-nonlinearity<0.01 for CIN; P-overall<0.01, P-nonlinearity = 0.01 for CIN I; P-overall <0.01, P-nonlinearity = 0.62 for CIN II/III). The highest prevalence of CIN was observed in women with high-risk HPV, who also had the lowest IL-2 levels (P-interaction < 0.01). Nested case-control study observed an inverse association between IL-2 levels and risk of CIN progression (OR=3.43, [1.17, 10.03]).

CONCLUSIONS

IL-2 levels in the local vaginal fluids were inversely associated with the risk of CIN in Chinese women either with or without high-risk HPV infection.

摘要

背景

白细胞介素-2（IL-2）长期以来一直与癌症的发展有关，但它在宫颈癌发展中的作用尚不清楚。很少有研究调查 IL-2 与高危型人乳头瘤病毒（HPV）与宫颈上皮内瘤变（CIN）风险之间的关联。

目的

我们旨在评估 IL-2 和高危 HPV 感染与 CIN 风险的关联以及它们在 CIN 风险上的相互作用。

设计

我们对 2285 名年龄在 19-65 岁的女性进行了横断面分析，这些女性参加了 2014-2015 年在中国山西进行的一项针对 40000 名女性的社区为基础的队列研究。我们使用分类和样条分析来评估局部阴道液中的 IL-2 与 CIN 患病率之间的关系。此外，还对 1503 名对照进行了随访，直至 2019 年 1 月 31 日），采用嵌套病例对照研究设计来评估阴道冲洗液中 IL-2 水平与 CIN 进展风险之间的关系。

结果

在调整了潜在的混杂因素后，IL-2 水平与 CIN 的患病率呈统计学上的负相关（第 1 四分位与第 4 四分位 IL-2 水平：相应的比值比[OR]和 95%置信区间[CI]分别为：CIN：1.75[1.37，2.23]；CIN I：1.32[1.01，1.73]；CIN II/III：3.53[2.26，5.52]）。升高的 IL-2 水平与 CIN 的患病率呈负相关（总体 P<0.01，CIN 呈非线性关系 P<0.01；总体 P<0.01，CIN I 呈非线性关系 P=0.01；总体 P<0.01，CIN II/III 呈非线性关系 P=0.62）。高危 HPV 感染的女性 CIN 患病率最高，同时 IL-2 水平也最低（P 交互作用<0.01）。嵌套病例对照研究观察到 IL-2 水平与 CIN 进展风险之间呈负相关（OR=3.43，[1.17，10.03]）。